CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7)
Three Libyan plants namely Ballota pseudodictamnus, Hedera helix, Thapsia garganica were tested for anticancer activity. The plants, collected from Aljabal-Al-Akhdar area of Libya in April 2010 were shed dried and subjected to Soxhlet extraction by methanol. Phytochemical screening indicated the pre...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2013-04-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/620/753 |
| _version_ | 1819032220356050944 |
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| author | Elmezogi Jamal Ben Hussien Gazala Erhuma Mabrouk Gadmour Manal Zetrini Abdulmotaleb Abdolgader Abossa Jamil Ahmad Shilpi |
| author_facet | Elmezogi Jamal Ben Hussien Gazala Erhuma Mabrouk Gadmour Manal Zetrini Abdulmotaleb Abdolgader Abossa Jamil Ahmad Shilpi |
| author_sort | Elmezogi Jamal |
| collection | DOAJ |
| description | Three Libyan plants namely Ballota pseudodictamnus, Hedera helix, Thapsia garganica were tested for anticancer activity. The plants, collected from Aljabal-Al-Akhdar area of Libya in April 2010 were shed dried and subjected to Soxhlet extraction by methanol. Phytochemical screening indicated the presence of 2-deoxy sugars, flavonoids, saponins and tannins but absence of alkaloids in all three plants under investigation. Antiproliferative activity was performed breast adenocarcinoma cell line (MCF7). At the concentration of 100µg/mL, B. pseudodictamnus, T. garganica and H. helix showed 90, 60 and 5% cell death, respectively as compared to the control. |
| first_indexed | 2024-12-21T06:58:29Z |
| format | Article |
| id | doaj.art-97b2ca04416d41099cac41881c9fd0a3 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-21T06:58:29Z |
| publishDate | 2013-04-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-97b2ca04416d41099cac41881c9fd0a32022-12-21T19:12:17ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862013-04-01242127130http://dx.doi.org/10.14499/indonesianjpharm24iss2pp127-130CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7)Elmezogi Jamal0Ben Hussien Gazala1Erhuma Mabrouk2Gadmour Manal3Zetrini Abdulmotaleb4Abdolgader Abossa5Jamil Ahmad Shilpi6Faculty of pharmacy, Univ. of Tripoli, Tripoli, Libya, 13645 Tripoli- LibyaFaculty of pharmacy, Univ. of Tripoli, Tripoli, Libya, 13645 Tripoli- LibyaNational Center for Medical Research, Zawia, 13642,LibyaFaculty of pharmacy, Univ. of Tripoli, Tripoli, Libya, 13645 Tripoli- LibyaNational Center for Medical Research, Zawia, 13642,LibyaFaculty of pharmacy, Univ. of Tripoli, Tripoli, Libya, 13645 Tripoli- LibyaPharmacy Discipline, Khulna Univ., 9208, BangladeshThree Libyan plants namely Ballota pseudodictamnus, Hedera helix, Thapsia garganica were tested for anticancer activity. The plants, collected from Aljabal-Al-Akhdar area of Libya in April 2010 were shed dried and subjected to Soxhlet extraction by methanol. Phytochemical screening indicated the presence of 2-deoxy sugars, flavonoids, saponins and tannins but absence of alkaloids in all three plants under investigation. Antiproliferative activity was performed breast adenocarcinoma cell line (MCF7). At the concentration of 100µg/mL, B. pseudodictamnus, T. garganica and H. helix showed 90, 60 and 5% cell death, respectively as compared to the control.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/620/753AntiproliferativeBreast adenocarcinomaCell l ine MCF-7 |
| spellingShingle | Elmezogi Jamal Ben Hussien Gazala Erhuma Mabrouk Gadmour Manal Zetrini Abdulmotaleb Abdolgader Abossa Jamil Ahmad Shilpi CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) Indonesian Journal of Pharmacy Antiproliferative Breast adenocarcinoma Cell l ine MCF-7 |
| title | CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) |
| title_full | CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) |
| title_fullStr | CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) |
| title_full_unstemmed | CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) |
| title_short | CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) |
| title_sort | cytotoxic activity of selected libyan medicinal plants on human breast adenocarcinoma cell line mcf 7 |
| topic | Antiproliferative Breast adenocarcinoma Cell l ine MCF-7 |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/620/753 |
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