Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis

Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis

De novo autoimmune hepatitis (DAIH) is an important cause of late allograft dysfunction following liver transplantation, but its cause and underlying pathogenesis remains unclear. We sought to identify specific innate and adaptive immune mechanisms driving the pro-inflammatory cytokine secreting reg...

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Bibliographic Details
Main Authors: Adam S. Arterbery, Jie Yao, Andrew Ling, Yaron Avitzur, Mercedes Martinez, Steven Lobritto, Yanhong Deng, Gan Geliang, Sameet Mehta, Guilin Wang, James Knight, Udeme D. Ekong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
innate immunity
toll-like receptors
inflammasome
Th1 regulatory T cells
liver transplantation
CD14++ monocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01612/full

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