Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations
Parental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast co...
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2021-12-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2021/12/Strilbytska_6_21.pdf |
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| author | O. M. Strilbytska N. P. Stefanyshyn U. V. Semaniuk O. V. Lushchak |
| author_facet | O. M. Strilbytska N. P. Stefanyshyn U. V. Semaniuk O. V. Lushchak |
| author_sort | O. M. Strilbytska |
| collection | DOAJ |
| description | Parental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast concentrations ranging from 0.25% to 15%. The subsequent generation was fed by the same diet, so the only variable in the experiments was the yeast concentration in the parental diet. We showed that protein restriction in the parental diet led to higher lactate dehydrogenase (LDH) activity in parents, and this effect was inherited in their progeny. The transgenerational effect of parental dietary yeast on malate dehydrogenase (MDH) activity was found only in males. An elevated level of dietary yeast was sufficient to enhance alanine transaminase ( ALT) and aspartate transaminase (AST) activity in parents, however, did not affect ALT activity and decreased AST in their offspring. A low yeast parental diet was shown to cause higher urea content in F1 males. It is concluded that parental dietary yeast plays a critical role in metabolic health that can be inherited through generation.Parental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast concentrations ranging from 0.25% to 15%. The subsequent generation was fed by the same diet, so the only variable in the experiments was the yeast concentration in the parental diet. We showed that protein restriction in the parental diet led to higher lactate dehydrogenase (LDH) activity in parents, and this effect was inherited in their progeny. The transgenerational effect of parental dietary yeast on malate dehydrogenase (MDH) activity was found only in males. An elevated level of dietary yeast was sufficient to enhance alanine transaminase ( ALT) and aspartate transaminase (AST) activity in parents, however, did not affect ALT activity and decreased AST in their offspring. A low yeast parental diet was shown to cause higher urea content in F1 males. It is concluded that parental dietary yeast plays a critical role in metabolic health that can be inherited through generation. |
| first_indexed | 2024-03-11T20:34:29Z |
| format | Article |
| id | doaj.art-97b4d3c54a7546f4b3db052baff2bbc3 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T20:34:29Z |
| publishDate | 2021-12-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-97b4d3c54a7546f4b3db052baff2bbc32023-10-02T07:19:13ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032021-12-0193611912910.15407/ubj93.06.119Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generationsO. M. Strilbytska0https://orcid.org/0000-0003-3277-2294N. P. Stefanyshyn1U. V. Semaniuk2https://orcid.org/0000-0001-9837-3769O. V. Lushchak3https://orcid.org/0000-0002-4627-1987Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, UkraineDepartment of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, UkraineDepartment of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, UkraineDepartment of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine; Research and Development University, Ivano-Frankivsk, UkraineParental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast concentrations ranging from 0.25% to 15%. The subsequent generation was fed by the same diet, so the only variable in the experiments was the yeast concentration in the parental diet. We showed that protein restriction in the parental diet led to higher lactate dehydrogenase (LDH) activity in parents, and this effect was inherited in their progeny. The transgenerational effect of parental dietary yeast on malate dehydrogenase (MDH) activity was found only in males. An elevated level of dietary yeast was sufficient to enhance alanine transaminase ( ALT) and aspartate transaminase (AST) activity in parents, however, did not affect ALT activity and decreased AST in their offspring. A low yeast parental diet was shown to cause higher urea content in F1 males. It is concluded that parental dietary yeast plays a critical role in metabolic health that can be inherited through generation.Parental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast concentrations ranging from 0.25% to 15%. The subsequent generation was fed by the same diet, so the only variable in the experiments was the yeast concentration in the parental diet. We showed that protein restriction in the parental diet led to higher lactate dehydrogenase (LDH) activity in parents, and this effect was inherited in their progeny. The transgenerational effect of parental dietary yeast on malate dehydrogenase (MDH) activity was found only in males. An elevated level of dietary yeast was sufficient to enhance alanine transaminase ( ALT) and aspartate transaminase (AST) activity in parents, however, did not affect ALT activity and decreased AST in their offspring. A low yeast parental diet was shown to cause higher urea content in F1 males. It is concluded that parental dietary yeast plays a critical role in metabolic health that can be inherited through generation.http://ukrbiochemjournal.org/wp-content/uploads/2021/12/Strilbytska_6_21.pdfdietfruit flymetabolismnutritionoffspringparentsproteinyeast |
| spellingShingle | O. M. Strilbytska N. P. Stefanyshyn U. V. Semaniuk O. V. Lushchak Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations The Ukrainian Biochemical Journal diet fruit fly metabolism nutrition offspring parents protein yeast |
| title | Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations |
| title_full | Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations |
| title_fullStr | Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations |
| title_full_unstemmed | Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations |
| title_short | Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations |
| title_sort | yeast concentration in the diet defines drosophila metabolism of both parental and offspring generations |
| topic | diet fruit fly metabolism nutrition offspring parents protein yeast |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2021/12/Strilbytska_6_21.pdf |
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