Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model
Alzheimer's disease is the most common disease underlying dementia in humans. Two major neuropathological hallmarks of AD are neuritic plaques primarily composed of amyloid beta peptide and neurofibrillary tangles primarily composed of hyperphosphorylated tau. In addition to impaired memory fun...
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Elsevier
2017-04-01
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| Series: | Journal of Pharmacological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861317300452 |
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| author | Eun-Jeong Yang Usman Mahmood Hyunju Kim Moonseok Choi Yunjung Choi Jean-Pyo Lee Moon-Jeong Chang Hye-Sun Kim |
| author_facet | Eun-Jeong Yang Usman Mahmood Hyunju Kim Moonseok Choi Yunjung Choi Jean-Pyo Lee Moon-Jeong Chang Hye-Sun Kim |
| author_sort | Eun-Jeong Yang |
| collection | DOAJ |
| description | Alzheimer's disease is the most common disease underlying dementia in humans. Two major neuropathological hallmarks of AD are neuritic plaques primarily composed of amyloid beta peptide and neurofibrillary tangles primarily composed of hyperphosphorylated tau. In addition to impaired memory function, AD patients often display neuropsychiatric symptoms and abnormal emotional states such as confusion, delusion, manic/depressive episodes and altered fear status. Brains from AD patients show atrophy of the amygdala which is involved in fear expression and emotional processing as well as hippocampal atrophy. However, which molecular changes are responsible for the altered emotional states observed in AD remains to be elucidated. Here, we observed that the fear response as assessed by evaluating fear memory via a cued fear conditioning test was impaired in 5XFamilial AD (5XFAD) mice, an animal model of AD. Compared to wild-type mice, 5XFAD mice showed changes in the phosphorylation of twelve proteins in the amygdala. Thus, our study provides twelve potential protein targets in the amygdala that may be responsible for the impairment in fear memory in AD. |
| first_indexed | 2024-12-13T06:23:24Z |
| format | Article |
| id | doaj.art-97b5a76a3e7c433bb1e5040d82e6e408 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T06:23:24Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-97b5a76a3e7c433bb1e5040d82e6e4082022-12-21T23:56:48ZengElsevierJournal of Pharmacological Sciences1347-86132017-04-01133426126710.1016/j.jphs.2017.03.005Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal modelEun-Jeong Yang0Usman Mahmood1Hyunju Kim2Moonseok Choi3Yunjung Choi4Jean-Pyo Lee5Moon-Jeong Chang6Hye-Sun Kim7Department of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaDepartment of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaDepartment of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaDepartment of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaDepartment of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 1430 Tulane Ave, SL99, New Orleans, LA 70112, USADepartment of Foods and Nutrition, College of Natural Science, Kookmin University, Seoul, Republic of KoreaDepartment of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, Republic of KoreaAlzheimer's disease is the most common disease underlying dementia in humans. Two major neuropathological hallmarks of AD are neuritic plaques primarily composed of amyloid beta peptide and neurofibrillary tangles primarily composed of hyperphosphorylated tau. In addition to impaired memory function, AD patients often display neuropsychiatric symptoms and abnormal emotional states such as confusion, delusion, manic/depressive episodes and altered fear status. Brains from AD patients show atrophy of the amygdala which is involved in fear expression and emotional processing as well as hippocampal atrophy. However, which molecular changes are responsible for the altered emotional states observed in AD remains to be elucidated. Here, we observed that the fear response as assessed by evaluating fear memory via a cued fear conditioning test was impaired in 5XFamilial AD (5XFAD) mice, an animal model of AD. Compared to wild-type mice, 5XFAD mice showed changes in the phosphorylation of twelve proteins in the amygdala. Thus, our study provides twelve potential protein targets in the amygdala that may be responsible for the impairment in fear memory in AD.http://www.sciencedirect.com/science/article/pii/S1347861317300452Alzheimer's diseaseAmygdalaCued fear conditioning5XFamilial Alzheimer's disease miceProtein phosphorylation |
| spellingShingle | Eun-Jeong Yang Usman Mahmood Hyunju Kim Moonseok Choi Yunjung Choi Jean-Pyo Lee Moon-Jeong Chang Hye-Sun Kim Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model Journal of Pharmacological Sciences Alzheimer's disease Amygdala Cued fear conditioning 5XFamilial Alzheimer's disease mice Protein phosphorylation |
| title | Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model |
| title_full | Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model |
| title_fullStr | Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model |
| title_full_unstemmed | Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model |
| title_short | Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model |
| title_sort | alterations in protein phosphorylation in the amygdala of the 5xfamilial alzheimer s disease animal model |
| topic | Alzheimer's disease Amygdala Cued fear conditioning 5XFamilial Alzheimer's disease mice Protein phosphorylation |
| url | http://www.sciencedirect.com/science/article/pii/S1347861317300452 |
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