Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19
Introduction. Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass endothelial damage followed by release of untypical large quantity of von...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-07-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1356 |
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| author | V. O. Bitsadze J. Kh. Khizroeva J.-Ch. Gris S. Schulman A. S. Shkoda M. V. Tretyakova N. A. Makatsariya E. V. Slukhanchuk L. L. Pankratyeva M. I. Petrovskiy I. V. Mashechkin D. V. Blinov V. I. Tsibizova Z. K. Gadaeva S. S. Panshin N. V. Samburova A. D. Makatsariya |
| author_facet | V. O. Bitsadze J. Kh. Khizroeva J.-Ch. Gris S. Schulman A. S. Shkoda M. V. Tretyakova N. A. Makatsariya E. V. Slukhanchuk L. L. Pankratyeva M. I. Petrovskiy I. V. Mashechkin D. V. Blinov V. I. Tsibizova Z. K. Gadaeva S. S. Panshin N. V. Samburova A. D. Makatsariya |
| author_sort | V. O. Bitsadze |
| collection | DOAJ |
| description | Introduction. Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass endothelial damage followed by release of untypical large quantity of von Willebrand factor (vWF) multimers and subsequent consumption of metalloproteinase ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) is described during severe COVID-19. The activation of innate immune cells including neutrophils results in formation of neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) release that, in turn, contributes to spread of inflammation and microvascular thrombosis.Aim: to evaluate a pathogenetic role and predictive significance for serum markers of inflammation, endothelial dysfunction and hemostatis activation such as vWF, ADAMTS-13 and MPO for in-hospital mortality in severe COVID-19 patients requiring mechanical lung ventilation.Materials and Methods. There was performed a single-center observational study with 129 severe COVID-19 patients on mechanical lung ventilation at the intensive care unit, by assessing serum in all subjects vWF, ADAMTS-13 as well as in 79 patients MPO level along with other potential predictors for in-hospital mortality.Results. A multivariate analysis revealed that increased serum level for vWF antigen (vWF:Ag) and MPO antigen (MPO:Ag) were significantly and independently related to high mortality probability: vWF:Ag (IU/ml) – adjusted odds ratio (OR) = 3.360; 95 % confidence interval (95 % Cl) = 1.562–7,228 (р = 0,0019); MPO:Ag (ng/ml) – adjusted OR = 1.062; 95 % = 1.024–1.101 (p = 0.0011). Such data allowed to obtained a simplified mortality score for categorizing patients as those having a higher or lower score compared with the median score level: a high score was associated with lower cumulative survival rate (p < 0.0001), with 50 % of the cases linked to lethal outcome on day 13 post-hospital admission.Conclusion. Severe COVID-19 patients requiring mechanical lung ventilation were found to have elevated level of serum MPO activity and vWF correlating with poor survival. |
| first_indexed | 2024-04-10T04:00:43Z |
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| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:00:43Z |
| publishDate | 2022-07-01 |
| publisher | IRBIS LLC |
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| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-97b5d765df81491aa9ec21f04639a5aa2023-03-13T07:09:52ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942022-07-0116322824310.17749/2313-7347/ob.gyn.rep.2022.327732Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19V. O. Bitsadze0J. Kh. Khizroeva1J.-Ch. Gris2S. Schulman3A. S. Shkoda4M. V. Tretyakova5N. A. Makatsariya6E. V. Slukhanchuk7L. L. Pankratyeva8M. I. Petrovskiy9I. V. Mashechkin10D. V. Blinov11V. I. Tsibizova12Z. K. Gadaeva13S. S. Panshin14N. V. Samburova15A. D. Makatsariya16Sechenov UniversitySechenov UniversitySechenov University; University of MontpellierSechenov University; McMaster UniversityVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentSechenov UniversitySechenov UniversitySechenov University; Petrovsky National Research Centre of SurgeryVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian FederationLomonosov Moscow State UniversityLomonosov Moscow State UniversityInstitute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical GroupAlmazov National Medical Research Centre, Health Ministry of Russian Federation«Medical Centre for Women» LLC«Medical Centre for Women» LLCSechenov UniversitySechenov UniversityIntroduction. Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass endothelial damage followed by release of untypical large quantity of von Willebrand factor (vWF) multimers and subsequent consumption of metalloproteinase ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) is described during severe COVID-19. The activation of innate immune cells including neutrophils results in formation of neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) release that, in turn, contributes to spread of inflammation and microvascular thrombosis.Aim: to evaluate a pathogenetic role and predictive significance for serum markers of inflammation, endothelial dysfunction and hemostatis activation such as vWF, ADAMTS-13 and MPO for in-hospital mortality in severe COVID-19 patients requiring mechanical lung ventilation.Materials and Methods. There was performed a single-center observational study with 129 severe COVID-19 patients on mechanical lung ventilation at the intensive care unit, by assessing serum in all subjects vWF, ADAMTS-13 as well as in 79 patients MPO level along with other potential predictors for in-hospital mortality.Results. A multivariate analysis revealed that increased serum level for vWF antigen (vWF:Ag) and MPO antigen (MPO:Ag) were significantly and independently related to high mortality probability: vWF:Ag (IU/ml) – adjusted odds ratio (OR) = 3.360; 95 % confidence interval (95 % Cl) = 1.562–7,228 (р = 0,0019); MPO:Ag (ng/ml) – adjusted OR = 1.062; 95 % = 1.024–1.101 (p = 0.0011). Such data allowed to obtained a simplified mortality score for categorizing patients as those having a higher or lower score compared with the median score level: a high score was associated with lower cumulative survival rate (p < 0.0001), with 50 % of the cases linked to lethal outcome on day 13 post-hospital admission.Conclusion. Severe COVID-19 patients requiring mechanical lung ventilation were found to have elevated level of serum MPO activity and vWF correlating with poor survival.https://www.gynecology.su/jour/article/view/1356covid-19adamts-13von willebrand factorvwfmyeloperoxydasemposurvival |
| spellingShingle | V. O. Bitsadze J. Kh. Khizroeva J.-Ch. Gris S. Schulman A. S. Shkoda M. V. Tretyakova N. A. Makatsariya E. V. Slukhanchuk L. L. Pankratyeva M. I. Petrovskiy I. V. Mashechkin D. V. Blinov V. I. Tsibizova Z. K. Gadaeva S. S. Panshin N. V. Samburova A. D. Makatsariya Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 Акушерство, гинекология и репродукция covid-19 adamts-13 von willebrand factor vwf myeloperoxydase mpo survival |
| title | Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 |
| title_full | Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 |
| title_fullStr | Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 |
| title_full_unstemmed | Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 |
| title_short | Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19 |
| title_sort | pathogenetic and prognostic significance of inflammation and altered adamts 13 vwf axis in patients with severe covid 19 |
| topic | covid-19 adamts-13 von willebrand factor vwf myeloperoxydase mpo survival |
| url | https://www.gynecology.su/jour/article/view/1356 |
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