<i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect
Background: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/10/9/1774 |
| _version_ | 1797487790764589056 |
|---|---|
| author | Maria-do-Céu Monteiro Alberto C. P. Dias Daniela Costa António Almeida-Dias Maria Begoña Criado |
| author_facet | Maria-do-Céu Monteiro Alberto C. P. Dias Daniela Costa António Almeida-Dias Maria Begoña Criado |
| author_sort | Maria-do-Céu Monteiro |
| collection | DOAJ |
| description | Background: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties. |
| first_indexed | 2024-03-09T23:52:49Z |
| format | Article |
| id | doaj.art-97b623ba1af94cc9aec1906989661f6d |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T23:52:49Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-97b623ba1af94cc9aec1906989661f6d2023-11-23T16:30:42ZengMDPI AGHealthcare2227-90322022-09-01109177410.3390/healthcare10091774<i>Hypericum perforatum</i> and Its Potential Antiplatelet EffectMaria-do-Céu Monteiro0Alberto C. P. Dias1Daniela Costa2António Almeida-Dias3Maria Begoña Criado4TOXRUN-CESPU Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, PortugalCITAB-UM-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalCITAB-UM-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, PortugalIA &HEALTH-CESPU Research Unit in Artificial Intelligence and Health, CESPU, CRL, 4585-116 Gandra, PortugalTOXRUN-CESPU Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, PortugalBackground: <i>Hypericum perforatum</i> (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (<i>Guan Ye Lian Qiao</i>) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties.https://www.mdpi.com/2227-9032/10/9/1774<i>Hypericum perforatum</i>platelet activationflow cytometrytraditional Chinese medicine |
| spellingShingle | Maria-do-Céu Monteiro Alberto C. P. Dias Daniela Costa António Almeida-Dias Maria Begoña Criado <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect Healthcare <i>Hypericum perforatum</i> platelet activation flow cytometry traditional Chinese medicine |
| title | <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect |
| title_full | <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect |
| title_fullStr | <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect |
| title_full_unstemmed | <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect |
| title_short | <i>Hypericum perforatum</i> and Its Potential Antiplatelet Effect |
| title_sort | i hypericum perforatum i and its potential antiplatelet effect |
| topic | <i>Hypericum perforatum</i> platelet activation flow cytometry traditional Chinese medicine |
| url | https://www.mdpi.com/2227-9032/10/9/1774 |
| work_keys_str_mv | AT mariadoceumonteiro ihypericumperforatumianditspotentialantiplateleteffect AT albertocpdias ihypericumperforatumianditspotentialantiplateleteffect AT danielacosta ihypericumperforatumianditspotentialantiplateleteffect AT antonioalmeidadias ihypericumperforatumianditspotentialantiplateleteffect AT mariabegonacriado ihypericumperforatumianditspotentialantiplateleteffect |