Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin.

Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin.

A group of peptides from the salivary gland of the tick Hyalomma marginatum rufipes, a vector of Crimean Congo hemorrhagic fever show weak similarity to the madanins, a group of thrombin-inhibitory peptides from a second tick species, Haemaphysalis longicornis. We have evaluated the anti-serine prot...

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Bibliographic Details
Main Authors: Willy Jablonka, Michalis Kotsyfakis, Daniella M Mizurini, Robson Q Monteiro, Jan Lukszo, Steven K Drake, José M C Ribeiro, John F Andersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4526366?pdf=render

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