Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors
There has been recent interest in epigenetics in psychiatry since it offers a means of understanding how stressful life experiences, in interaction with the genotype, result in epigenetic changes that result in altered gene expression, ultimately affecting the risk for mental disorders. Many studies...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00369/full |
| _version_ | 1811270988336201728 |
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| author | Nikolaos P Daskalakis Nikolaos P Daskalakis Rachel eYehuda Rachel eYehuda |
| author_facet | Nikolaos P Daskalakis Nikolaos P Daskalakis Rachel eYehuda Rachel eYehuda |
| author_sort | Nikolaos P Daskalakis |
| collection | DOAJ |
| description | There has been recent interest in epigenetics in psychiatry since it offers a means of understanding how stressful life experiences, in interaction with the genotype, result in epigenetic changes that result in altered gene expression, ultimately affecting the risk for mental disorders. Many studies focused on methylation of the glucocorticoid receptor exon 1F promoter following an initial observation that changes in this region could be modulated by the environment. This review examines all published studies that have attempted to measure methylation in this region using different techniques, several tissue types, populations at different behavioral state and stages of development. Methodological issues have been raised with the aim of attempting to understand methylation quantification and site of action. We propose that it is useful to examine whether methylation at specific sites within the promoter region may be particularly relevant to psychiatric vulnerability to stress-related outcomes. |
| first_indexed | 2024-04-12T22:13:13Z |
| format | Article |
| id | doaj.art-97b997c4f6bc4508be39f9c31ec773db |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T22:13:13Z |
| publishDate | 2014-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-97b997c4f6bc4508be39f9c31ec773db2022-12-22T03:14:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2014-11-01810.3389/fnins.2014.00369116091Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factorsNikolaos P Daskalakis0Nikolaos P Daskalakis1Rachel eYehuda2Rachel eYehuda3Icahn School of Medicine at Mount SinaiJames J. Peters Veterans Affairs Medical CenterIcahn School of Medicine at Mount SinaiJames J. Peters Veterans Affairs Medical CenterThere has been recent interest in epigenetics in psychiatry since it offers a means of understanding how stressful life experiences, in interaction with the genotype, result in epigenetic changes that result in altered gene expression, ultimately affecting the risk for mental disorders. Many studies focused on methylation of the glucocorticoid receptor exon 1F promoter following an initial observation that changes in this region could be modulated by the environment. This review examines all published studies that have attempted to measure methylation in this region using different techniques, several tissue types, populations at different behavioral state and stages of development. Methodological issues have been raised with the aim of attempting to understand methylation quantification and site of action. We propose that it is useful to examine whether methylation at specific sites within the promoter region may be particularly relevant to psychiatric vulnerability to stress-related outcomes.http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00369/fullPsychiatryPsychopathologydevelopmentadversityGlucocorticoid receptorpromoter methylation |
| spellingShingle | Nikolaos P Daskalakis Nikolaos P Daskalakis Rachel eYehuda Rachel eYehuda Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors Frontiers in Neuroscience Psychiatry Psychopathology development adversity Glucocorticoid receptor promoter methylation |
| title | Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors |
| title_full | Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors |
| title_fullStr | Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors |
| title_full_unstemmed | Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors |
| title_short | Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic Review of contributing factors |
| title_sort | site specific methylation changes in the glucocorticoid receptor exon 1f promoter in relation to life adversity systematic review of contributing factors |
| topic | Psychiatry Psychopathology development adversity Glucocorticoid receptor promoter methylation |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00369/full |
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