Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study
Purpose: To evaluate whether perioperative N-acetylcysteine (NAC) administration reduces the risk of cardiac surgery associated acute kidney injury (CSA-AKI). Materials and Methods: A systematic literature review (Medline, PubMed, Cochrane, Biomedical central, Google Scholar) identified 10 studies (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2016.1269853 |
| _version_ | 1797684553141190656 |
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| author | Mei Mei Hong-Wen Zhao Qian-Guang Pan You-Min Pu Mao-Zhi Tang Bing-Bing Shen |
| author_facet | Mei Mei Hong-Wen Zhao Qian-Guang Pan You-Min Pu Mao-Zhi Tang Bing-Bing Shen |
| author_sort | Mei Mei |
| collection | DOAJ |
| description | Purpose: To evaluate whether perioperative N-acetylcysteine (NAC) administration reduces the risk of cardiac surgery associated acute kidney injury (CSA-AKI). Materials and Methods: A systematic literature review (Medline, PubMed, Cochrane, Biomedical central, Google Scholar) identified 10 studies (1391 patients; 695 NAC and 696 placebo) that compared the efficacy and adverse effects of perioperative NAC administration for CSA-AKI prevention in adults undergoing elective cardiac surgery. Meta-analysis was performed using Comprehensive Meta-Analysis statistical software. Results: Patients in the NAC-treated and placebo groups had similar rate of CSA-AKI occurrence, change in creatinine levels, as well as the in-hospital mortality rate (RR = 0.841, 95% CI = 0.691 to 1.023, p = 0.083; pooled difference in means = −0.328, 95% CI = −0.712 to 0.056, p = 0.094; RR = 0.741, 95% CI = 0.388 to 1.418, p = 0.366, respectively). Conclusions: Our study does not support perioperative NAC administration as a mean to reduce the risk of CSA-AKI. |
| first_indexed | 2024-03-12T00:32:20Z |
| format | Article |
| id | doaj.art-97be5dfa4903437b832ee99d21a653d3 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:32:20Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-97be5dfa4903437b832ee99d21a653d32023-09-15T10:12:27ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532018-01-01311142310.1080/08941939.2016.12698531269853Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis StudyMei Mei0Hong-Wen Zhao1Qian-Guang Pan2You-Min Pu3Mao-Zhi Tang4Bing-Bing Shen5Southwest Hospital, Third Military Medical UniversitySouthwest Hospital, Third Military Medical UniversitySouthwest Hospital, Third Military Medical UniversitySouthwest Hospital, Third Military Medical UniversitySouthwest Hospital, Third Military Medical UniversitySouthwest Hospital, Third Military Medical UniversityPurpose: To evaluate whether perioperative N-acetylcysteine (NAC) administration reduces the risk of cardiac surgery associated acute kidney injury (CSA-AKI). Materials and Methods: A systematic literature review (Medline, PubMed, Cochrane, Biomedical central, Google Scholar) identified 10 studies (1391 patients; 695 NAC and 696 placebo) that compared the efficacy and adverse effects of perioperative NAC administration for CSA-AKI prevention in adults undergoing elective cardiac surgery. Meta-analysis was performed using Comprehensive Meta-Analysis statistical software. Results: Patients in the NAC-treated and placebo groups had similar rate of CSA-AKI occurrence, change in creatinine levels, as well as the in-hospital mortality rate (RR = 0.841, 95% CI = 0.691 to 1.023, p = 0.083; pooled difference in means = −0.328, 95% CI = −0.712 to 0.056, p = 0.094; RR = 0.741, 95% CI = 0.388 to 1.418, p = 0.366, respectively). Conclusions: Our study does not support perioperative NAC administration as a mean to reduce the risk of CSA-AKI.http://dx.doi.org/10.1080/08941939.2016.1269853n-acetylcysteineacute kidney injury/kidney injurycardiac surgery/heart surgerycoronary artery bypasscreatininemeta-analysis |
| spellingShingle | Mei Mei Hong-Wen Zhao Qian-Guang Pan You-Min Pu Mao-Zhi Tang Bing-Bing Shen Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study Journal of Investigative Surgery n-acetylcysteine acute kidney injury/kidney injury cardiac surgery/heart surgery coronary artery bypass creatinine meta-analysis |
| title | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
| title_full | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
| title_fullStr | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
| title_full_unstemmed | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
| title_short | Efficacy of N-Acetylcysteine in Preventing Acute Kidney Injury After Cardiac Surgery: A Meta-Analysis Study |
| title_sort | efficacy of n acetylcysteine in preventing acute kidney injury after cardiac surgery a meta analysis study |
| topic | n-acetylcysteine acute kidney injury/kidney injury cardiac surgery/heart surgery coronary artery bypass creatinine meta-analysis |
| url | http://dx.doi.org/10.1080/08941939.2016.1269853 |
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