Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased. Environmental endocrine disruptors (EEDs) are chemicals that may interfere with the endocrine system...

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Bibliographic Details
Main Authors: Mengnan Lu, Ruoyang Feng, Yujie Qin, Hongyang Deng, Biyao Lian, Chunyan Yin, Yanfeng Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Endocrinology
Subjects:
menarche
puberty
environmental endocrine disruptor
GWAS
TWAS
CGSEA
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.836527/full

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