The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries
Background: Diabetes mellitus is a major cardiovascular risk factor for the development of coronary artery disease, but knowledge about the impact of diabetes mellitus on the outcome of patients with myocardial infarction with non-obstructive coronary arteries is limited. The aim of this study was t...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724000162 |
| _version_ | 1797301400381685760 |
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| author | Fabienne Kreimer Clara Schlettert Mohammad Abumayyaleh Ibrahim Akin Mido Max Hijazi Nazha Hamdani Michael Gotzmann Andreas Mügge Ibrahim El-Battrawy Assem Aweimer |
| author_facet | Fabienne Kreimer Clara Schlettert Mohammad Abumayyaleh Ibrahim Akin Mido Max Hijazi Nazha Hamdani Michael Gotzmann Andreas Mügge Ibrahim El-Battrawy Assem Aweimer |
| author_sort | Fabienne Kreimer |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a major cardiovascular risk factor for the development of coronary artery disease, but knowledge about the impact of diabetes mellitus on the outcome of patients with myocardial infarction with non-obstructive coronary arteries is limited. The aim of this study was to investigate the prognostic impact of diabetes mellitus on in- and out-of-hospital adverse events in troponin-positive patients with non-obstructive coronary arteries. Methods and Results: A total of 373 troponin-positive patients with non-obstructive coronary arteries between 2010 and 2021 at Bergmannsheil University Hospital Bochum were enrolled, including 65 diabetics and 307 nondiabetics. The median follow-up was 6.2 years. The primary study end point was a composite of in-hospital major adverse cardiovascular events (MACE). Secondary endpoints covered MACE during follow-up.Mean age of the study cohort was 62.9 years and 49.3 % were male. Although the overall rate of in-hospital MACE was higher in diabetics (41.5 %) than in non-diabetics (33.9 %), this difference did not reach statistical significance (p = 0.240). The in-hospital mortality rate was low in both groups, 0 % of diabetes group versus 2.9 % of non-diabetic patients. During follow-up, diabetic patients had a significantly higher rate of MACE (51.9 % vs. 31.1 %, p = 0.004) and a significantly higher all-cause mortality rate than non-diabetic patients (42.3 % vs. 20.1 %, p < 0.001). Conclusion: Our study reveals that the impact of diabetes mellitus on cardiovascular outcomes in troponin-positive patients with non-obstructive coronary arteries intensifies over the long term, leading to increased rates of both cardiovascular adverse events and overall mortality. |
| first_indexed | 2024-03-07T23:22:00Z |
| format | Article |
| id | doaj.art-97c0ddf7272e47c68f3f9bce2d7ed276 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-07T23:22:00Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-97c0ddf7272e47c68f3f9bce2d7ed2762024-02-21T05:29:06ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-02-0150101350The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteriesFabienne Kreimer0Clara Schlettert1Mohammad Abumayyaleh2Ibrahim Akin3Mido Max Hijazi4Nazha Hamdani5Michael Gotzmann6Andreas Mügge7Ibrahim El-Battrawy8Assem Aweimer9Department of Cardiology and Rhythmology, University Hospital St. Josef Hospital Bochum, Ruhr University Bochum, Bochum, GermanyDepartment of Cardiology and Angiology, Bergmannsheil University Hospital, Ruhr University of Bochum, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, GermanyFirst Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, GermanyTechnische Universität Dresden, Faculty of Medicine, and University Hospital Carl Gustav Carus, Department of Neurosurgery, Division of Spine Surgery, GermanyInstitute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, GermanyDepartment of Cardiology and Rhythmology, University Hospital St. Josef Hospital Bochum, Ruhr University Bochum, Bochum, GermanyDepartment of Cardiology and Rhythmology, University Hospital St. Josef Hospital Bochum, Ruhr University Bochum, Bochum, Germany; Department of Cardiology and Angiology, Bergmannsheil University Hospital, Ruhr University of Bochum, GermanyDepartment of Cardiology and Angiology, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany; Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, Bochum, Germany; Corresponding author.Department of Cardiology and Angiology, Bergmannsheil University Hospital, Ruhr University of Bochum, GermanyBackground: Diabetes mellitus is a major cardiovascular risk factor for the development of coronary artery disease, but knowledge about the impact of diabetes mellitus on the outcome of patients with myocardial infarction with non-obstructive coronary arteries is limited. The aim of this study was to investigate the prognostic impact of diabetes mellitus on in- and out-of-hospital adverse events in troponin-positive patients with non-obstructive coronary arteries. Methods and Results: A total of 373 troponin-positive patients with non-obstructive coronary arteries between 2010 and 2021 at Bergmannsheil University Hospital Bochum were enrolled, including 65 diabetics and 307 nondiabetics. The median follow-up was 6.2 years. The primary study end point was a composite of in-hospital major adverse cardiovascular events (MACE). Secondary endpoints covered MACE during follow-up.Mean age of the study cohort was 62.9 years and 49.3 % were male. Although the overall rate of in-hospital MACE was higher in diabetics (41.5 %) than in non-diabetics (33.9 %), this difference did not reach statistical significance (p = 0.240). The in-hospital mortality rate was low in both groups, 0 % of diabetes group versus 2.9 % of non-diabetic patients. During follow-up, diabetic patients had a significantly higher rate of MACE (51.9 % vs. 31.1 %, p = 0.004) and a significantly higher all-cause mortality rate than non-diabetic patients (42.3 % vs. 20.1 %, p < 0.001). Conclusion: Our study reveals that the impact of diabetes mellitus on cardiovascular outcomes in troponin-positive patients with non-obstructive coronary arteries intensifies over the long term, leading to increased rates of both cardiovascular adverse events and overall mortality.http://www.sciencedirect.com/science/article/pii/S2352906724000162MINOCADiabetes mellitusMajor adverse cardiovascular events |
| spellingShingle | Fabienne Kreimer Clara Schlettert Mohammad Abumayyaleh Ibrahim Akin Mido Max Hijazi Nazha Hamdani Michael Gotzmann Andreas Mügge Ibrahim El-Battrawy Assem Aweimer The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries International Journal of Cardiology: Heart & Vasculature MINOCA Diabetes mellitus Major adverse cardiovascular events |
| title | The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries |
| title_full | The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries |
| title_fullStr | The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries |
| title_full_unstemmed | The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries |
| title_short | The impact of diabetes mellitus on the outcome of troponin-positive patients with non-obstructive coronary arteries |
| title_sort | impact of diabetes mellitus on the outcome of troponin positive patients with non obstructive coronary arteries |
| topic | MINOCA Diabetes mellitus Major adverse cardiovascular events |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724000162 |
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