Death Receptor 5 Displayed on Extracellular Vesicles Decreases TRAIL Sensitivity of Colon Cancer Cells

Death Receptor 5 Displayed on Extracellular Vesicles Decreases TRAIL Sensitivity of Colon Cancer Cells

Tumor necrosis factor–related apoptosis inducing ligand (TRAIL) is considered to be a promising antitumor drug because of its selective proapoptotic properties on tumor cells. However, the clinical application of TRAIL is until now limited because of the resistance of several cancer cells, which can...

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Bibliographic Details
Main Authors: Rita Setroikromo, Baojie Zhang, Carlos R. Reis, Rima H. Mistry, Wim J. Quax
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular vesicles
DR5
TRAIL
apoptosis
conditioned medium
receptor–ligand trafficking
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00318/full

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