Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410<sup>6.30×30</sup>K Variant in the Histamine H<sub>1</sub> Receptor

Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410<sup>6.30×30</sup>K Variant in the Histamine H<sub>1</sub> Receptor

The Exome Aggregation Consortium has collected the protein-encoding DNA sequences of almost 61,000 unrelated humans. Analysis of this dataset for G protein-coupled receptor (GPCR) proteins (available at GPCRdb) revealed a total of 463 naturally occurring genetic missense variations in the histamine...

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Bibliographic Details
Main Authors: Xiaoyuan Ma, Marta Arimont Segura, Barbara Zarzycka, Henry F. Vischer, Rob Leurs
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
missense variation
G protein-coupled receptor
histamine H<sub>1</sub> receptor
ionic lock
constitutive activity
Online Access:https://www.mdpi.com/1422-0067/22/7/3702

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