Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a]
In this study, we created LDL receptor (LDLr) defective (WHHL) transgenic rabbits expressing human apo[a] to examine whether LDLr mediates the Lp[a] clearance from the plasma. By crossbreeding WHHL rabbits with human apo[a] transgenic rabbits, we obtained two groups of human apo[a] transgenic rabbit...
Main Authors: | Jianglin Fan, Mireille Challah, Hiroaki Shimoyamada, Masashi Shiomi, Santica Marcovina, Teruo Watanabe |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2000-06-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520320435 |
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