Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation
Introduction: Lymphadenopathy is a very common condition for which excision biopsy is often recommended when fine needle aspiration cytology is not conclusive. Lymph node imprint cytology is a useful and rapid alternative diagnostic tool. This study was conducted to assess the accuracy of lymph node...
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| Format: | Article |
| Language: | English |
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HEAD Nepal
2019-06-01
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| Series: | Nepalese Medical Journal |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/nmj/article/view/24053 |
| _version_ | 1818692965351030784 |
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| author | Prabesh Kumar Choudhary Niraj Nepal Nirajan Mainali Gaurav Chhetri |
| author_facet | Prabesh Kumar Choudhary Niraj Nepal Nirajan Mainali Gaurav Chhetri |
| author_sort | Prabesh Kumar Choudhary |
| collection | DOAJ |
| description | Introduction: Lymphadenopathy is a very common condition for which excision biopsy is often recommended when fine needle aspiration cytology is not conclusive. Lymph node imprint cytology is a useful and rapid alternative diagnostic tool. This study was conducted to assess the accuracy of lymph node imprint cytology as compared to the histopathology.
Materials and Methods: Imprint smears were made from all cases of lymphadenopathy. The smears were evaluated by three pathologists and categorized into, inflammatory lesions and primary and metastatic tumors. Imprint smears were made from lymph node excision specimens and were stained with PAP and MGG stains. The diagnosis in imprints was compared with those given by histopathology. With the help of sensitivity, specificity & accuracy, the agreement between the imprint smear and histopathology was determined.
Results: Among the total 92 cases, 40 (43.4%) cases were chronic non-specific lymphadenitis, 22 (23.9%) were tuberculosis and metastatic lesions each. The overall accuracy of lymph node imprint cytology was 96.73%, 96.74%, 96.74% and 100% for tuberculosis, chronic non-specific lymphadenitis, lymphoma, and metastatic lesions respectively.
Conclusions: Lymph node imprint smears is a rapid diagnostic tool and can be used routinely as an adjunct to histopathology in the diagnosis of various lymph node disorders. |
| first_indexed | 2024-12-17T13:06:10Z |
| format | Article |
| id | doaj.art-97c21f97317a490ca91ea1b9808faabf |
| institution | Directory Open Access Journal |
| issn | 2631-2093 2645-8586 |
| language | English |
| last_indexed | 2024-12-17T13:06:10Z |
| publishDate | 2019-06-01 |
| publisher | HEAD Nepal |
| record_format | Article |
| series | Nepalese Medical Journal |
| spelling | doaj.art-97c21f97317a490ca91ea1b9808faabf2022-12-21T21:47:14ZengHEAD NepalNepalese Medical Journal2631-20932645-85862019-06-012113814010.3126/nmj.v2i1.2405324053Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological CorrelationPrabesh Kumar Choudhary0Niraj Nepal1Nirajan Mainali2Gaurav Chhetri3Nobel Medical College Teaching Hospital and Research Centre, Biratnagar, NepalNobel Medical College Teaching Hospital and Research Centre, Biratnagar, NepalNobel Medical College Teaching Hospital and Research Centre, Biratnagar, NepalNobel Medical College Teaching Hospital and Research Centre, Biratnagar, NepalIntroduction: Lymphadenopathy is a very common condition for which excision biopsy is often recommended when fine needle aspiration cytology is not conclusive. Lymph node imprint cytology is a useful and rapid alternative diagnostic tool. This study was conducted to assess the accuracy of lymph node imprint cytology as compared to the histopathology. Materials and Methods: Imprint smears were made from all cases of lymphadenopathy. The smears were evaluated by three pathologists and categorized into, inflammatory lesions and primary and metastatic tumors. Imprint smears were made from lymph node excision specimens and were stained with PAP and MGG stains. The diagnosis in imprints was compared with those given by histopathology. With the help of sensitivity, specificity & accuracy, the agreement between the imprint smear and histopathology was determined. Results: Among the total 92 cases, 40 (43.4%) cases were chronic non-specific lymphadenitis, 22 (23.9%) were tuberculosis and metastatic lesions each. The overall accuracy of lymph node imprint cytology was 96.73%, 96.74%, 96.74% and 100% for tuberculosis, chronic non-specific lymphadenitis, lymphoma, and metastatic lesions respectively. Conclusions: Lymph node imprint smears is a rapid diagnostic tool and can be used routinely as an adjunct to histopathology in the diagnosis of various lymph node disorders.https://www.nepjol.info/index.php/nmj/article/view/24053CarcinomaImprintLymph nodeTuberculosis |
| spellingShingle | Prabesh Kumar Choudhary Niraj Nepal Nirajan Mainali Gaurav Chhetri Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation Nepalese Medical Journal Carcinoma Imprint Lymph node Tuberculosis |
| title | Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation |
| title_full | Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation |
| title_fullStr | Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation |
| title_full_unstemmed | Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation |
| title_short | Diagnostic Role of Lymphnode Imprint: A Cyto-histopathological Correlation |
| title_sort | diagnostic role of lymphnode imprint a cyto histopathological correlation |
| topic | Carcinoma Imprint Lymph node Tuberculosis |
| url | https://www.nepjol.info/index.php/nmj/article/view/24053 |
| work_keys_str_mv | AT prabeshkumarchoudhary diagnosticroleoflymphnodeimprintacytohistopathologicalcorrelation AT nirajnepal diagnosticroleoflymphnodeimprintacytohistopathologicalcorrelation AT nirajanmainali diagnosticroleoflymphnodeimprintacytohistopathologicalcorrelation AT gauravchhetri diagnosticroleoflymphnodeimprintacytohistopathologicalcorrelation |