Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy
Several breakthroughs have been achieved in anti-tumor immune checkpoint blockade (ICB) therapy in the past decade. Despite the considerable therapeutic effects, ICB is still limited by the low benefit rates and severe systemic toxicity. Pre-clinical studies have shown that photothermal therapy (PTT...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522002775 |
| _version_ | 1818232339842465792 |
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| author | Xinlun Dai Xin Li Yahui Liu Fei Yan |
| author_facet | Xinlun Dai Xin Li Yahui Liu Fei Yan |
| author_sort | Xinlun Dai |
| collection | DOAJ |
| description | Several breakthroughs have been achieved in anti-tumor immune checkpoint blockade (ICB) therapy in the past decade. Despite the considerable therapeutic effects, ICB is still limited by the low benefit rates and severe systemic toxicity. Pre-clinical studies have shown that photothermal therapy (PTT) mediated by nanoparticles (NPs) can counterbalance the drawbacks of ICB therapy and produce synergistic anti-tumor effects. NPs offer several advantages such as increased tumor-targeting ability, high drug-loading capacity and satisfying biocompatibility. Therefore, combining NPs-based PTT and ICB therapy can achieve a better outcome against tumors, and even prevent metastatic and recurrence by inducing immune memory. Here, we have discussed the current progress in ICB therapy and NPs-based PTT, along with the pre-clinical trials on PTT/ICB combinational therapy. The synthesis and mechanisms of different photothermal NPs have also been summarized. Moreover, the current challenges, deficiencies and future improvement of this novel treatment modality have been analyzed. |
| first_indexed | 2024-12-12T11:04:43Z |
| format | Article |
| id | doaj.art-97c2f000f0e74af2a616deac6fbeb088 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-12T11:04:43Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-97c2f000f0e74af2a616deac6fbeb0882022-12-22T00:26:27ZengElsevierMaterials & Design0264-12752022-05-01217110656Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapyXinlun Dai0Xin Li1Yahui Liu2Fei Yan3Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Dermatology and Venerology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China; Corresponding authors.State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), International Research Center for Chemistry-Medicine Joint Innovation, College of Chemistry, Jilin University, Changchun 130012, China; Corresponding authors.Several breakthroughs have been achieved in anti-tumor immune checkpoint blockade (ICB) therapy in the past decade. Despite the considerable therapeutic effects, ICB is still limited by the low benefit rates and severe systemic toxicity. Pre-clinical studies have shown that photothermal therapy (PTT) mediated by nanoparticles (NPs) can counterbalance the drawbacks of ICB therapy and produce synergistic anti-tumor effects. NPs offer several advantages such as increased tumor-targeting ability, high drug-loading capacity and satisfying biocompatibility. Therefore, combining NPs-based PTT and ICB therapy can achieve a better outcome against tumors, and even prevent metastatic and recurrence by inducing immune memory. Here, we have discussed the current progress in ICB therapy and NPs-based PTT, along with the pre-clinical trials on PTT/ICB combinational therapy. The synthesis and mechanisms of different photothermal NPs have also been summarized. Moreover, the current challenges, deficiencies and future improvement of this novel treatment modality have been analyzed.http://www.sciencedirect.com/science/article/pii/S0264127522002775NanoparticlesPhotothermal therapyImmune checkpoint blockadeTumor microenvironmentImmunogenic cell death |
| spellingShingle | Xinlun Dai Xin Li Yahui Liu Fei Yan Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy Materials & Design Nanoparticles Photothermal therapy Immune checkpoint blockade Tumor microenvironment Immunogenic cell death |
| title | Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy |
| title_full | Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy |
| title_fullStr | Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy |
| title_full_unstemmed | Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy |
| title_short | Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy |
| title_sort | recent advances in nanoparticles based photothermal therapy synergizing with immune checkpoint blockade therapy |
| topic | Nanoparticles Photothermal therapy Immune checkpoint blockade Tumor microenvironment Immunogenic cell death |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522002775 |
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