The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction
Background The anticoagulation and risk factors in atrial fibrillation (ATRIA) score is associated with adverse cardiovascular events. However, its relationship with coronary thrombus burden is unclear. Therefore, we aimed to investigate the relationship between the ATRIA score and thrombus burden i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241237232 |
| _version_ | 1827275918486274048 |
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| author | Gökhan Coşkun MD Cem Ozde MD Osman Kayapinar MD Gulsah Aktore MD Ensar Ekşi MD Hamdi Afşin MD Ahmet Egemen Sayın |
| author_facet | Gökhan Coşkun MD Cem Ozde MD Osman Kayapinar MD Gulsah Aktore MD Ensar Ekşi MD Hamdi Afşin MD Ahmet Egemen Sayın |
| author_sort | Gökhan Coşkun MD |
| collection | DOAJ |
| description | Background The anticoagulation and risk factors in atrial fibrillation (ATRIA) score is associated with adverse cardiovascular events. However, its relationship with coronary thrombus burden is unclear. Therefore, we aimed to investigate the relationship between the ATRIA score and thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI). Materials and Methods The study was designed as a prospective cross-sectional observational study. Our study included 319 patients who were prospectively admitted with STEMI between January 2021 and April 2022. Patients were divided into 2 groups with low thrombus burden (LTB) (grade <3) and high thrombus burden (HTB) (grade ≥3). ATRIA score was calculated and recorded for all patients. ATRIA scores of both groups were compared. Results In our study, 58.9% ( n = 188) of patients in the LTB group and 41% ( n = 131) of patients in the HTB group. The ATRIA risk score ( p < .001) was significantly higher in the HTB group. In multivariate logistic regression analysis, ATRIA score, glomerular filtration rate, hypertensıon, abciximab usage, and no-reflow were found to be independent predictors of HTB in STEMI patients undergoing primary PCI. In receiver operating characteristic analysis, ATRIA score >4 had a sensitivity of 66.2% and specificity of 95.2%, and ATRIA score >8 sensitivity of 98% and specificity of 100% predicted HTB. Conclusion In this study, we found that thrombus burden may be associated with ATRIA risk score in patients presenting with STEMI. |
| first_indexed | 2024-04-24T05:52:30Z |
| format | Article |
| id | doaj.art-97c30cedcb8b41ab83a95b55f4a5ff46 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-24T05:52:30Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-97c30cedcb8b41ab83a95b55f4a5ff462024-04-23T10:03:45ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232024-04-013010.1177/10760296241237232The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial InfarctionGökhan Coşkun MD0Cem Ozde MD1Osman Kayapinar MD2Gulsah Aktore MD3Ensar Ekşi MD4Hamdi Afşin MD5Ahmet Egemen Sayın6 , Duzce, Turkey , Duzce, Turkey , Duzce, Turkey , Duzce, Turkey , Duzce, Turkey , Duzce, Turkey , Duzce, TurkeyBackground The anticoagulation and risk factors in atrial fibrillation (ATRIA) score is associated with adverse cardiovascular events. However, its relationship with coronary thrombus burden is unclear. Therefore, we aimed to investigate the relationship between the ATRIA score and thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI). Materials and Methods The study was designed as a prospective cross-sectional observational study. Our study included 319 patients who were prospectively admitted with STEMI between January 2021 and April 2022. Patients were divided into 2 groups with low thrombus burden (LTB) (grade <3) and high thrombus burden (HTB) (grade ≥3). ATRIA score was calculated and recorded for all patients. ATRIA scores of both groups were compared. Results In our study, 58.9% ( n = 188) of patients in the LTB group and 41% ( n = 131) of patients in the HTB group. The ATRIA risk score ( p < .001) was significantly higher in the HTB group. In multivariate logistic regression analysis, ATRIA score, glomerular filtration rate, hypertensıon, abciximab usage, and no-reflow were found to be independent predictors of HTB in STEMI patients undergoing primary PCI. In receiver operating characteristic analysis, ATRIA score >4 had a sensitivity of 66.2% and specificity of 95.2%, and ATRIA score >8 sensitivity of 98% and specificity of 100% predicted HTB. Conclusion In this study, we found that thrombus burden may be associated with ATRIA risk score in patients presenting with STEMI.https://doi.org/10.1177/10760296241237232 |
| spellingShingle | Gökhan Coşkun MD Cem Ozde MD Osman Kayapinar MD Gulsah Aktore MD Ensar Ekşi MD Hamdi Afşin MD Ahmet Egemen Sayın The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction Clinical and Applied Thrombosis/Hemostasis |
| title | The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction |
| title_full | The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction |
| title_fullStr | The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction |
| title_full_unstemmed | The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction |
| title_short | The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction |
| title_sort | relationship of coronary thrombus burden and anticoagulation and risk factors in atrial fibrillation atria score in patients with st segment elevation myocardial infarction |
| url | https://doi.org/10.1177/10760296241237232 |
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