Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets
The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental test samples of mixtures of the plant substance...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2023-11-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/287001/284228 |
| _version_ | 1797626840158830592 |
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| author | N. А. Symonenko O. S. Shpychak O. S. Kukhtenko Ye. A. Bezrukavyi H. B. Yurieva |
| author_facet | N. А. Symonenko O. S. Shpychak O. S. Kukhtenko Ye. A. Bezrukavyi H. B. Yurieva |
| author_sort | N. А. Symonenko |
| collection | DOAJ |
| description | The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE).
Materials and methods. Experimental test samples of mixtures of the plant substance of domestic origin CPHTE with groups of excipients, approved for medical use, were used as the object of research.
Results. We conducted experimental research by a mathematical planning method called the Greek–Latin square. In this study, we investigated how 16 different auxiliary substances affected the pharmacotechnological properties of tableting masses and tablets made from PPTEG with cardioprotective properties. Our goal was to determine the optimal composition and manufacturing process for a medication, specifically “Pastinocard” tablets. We also developed project plans for manufacturing regulations and quality control methods, which we successfully tested in the industrial production setting at Pharmaceutical Company “Zdorovye”, LTD in Kharkiv.
Conclusions. The formulation for cardioprotective tablets, designated as “Pastinocard”, has been both theoretically justified and experimentally developed by domestic CPHTE raw materials. These research findings have been instrumental in crafting the regulatory documentation for quality control and the production processes of the resulting tablet medication. |
| first_indexed | 2024-03-11T10:15:56Z |
| format | Article |
| id | doaj.art-97c52fe0f6094676a423c27a0b1fa7fc |
| institution | Directory Open Access Journal |
| issn | 2306-8094 2409-2932 |
| language | English |
| last_indexed | 2024-03-11T10:15:56Z |
| publishDate | 2023-11-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj.art-97c52fe0f6094676a423c27a0b1fa7fc2023-11-16T09:38:06ZengZaporozhye State Medical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322023-11-0116323624310.14739/2409-2932.2023.3.287001Justification of the choice of excipients during the development of the composition of “Pastinocard” tabletsN. А. Symonenko0https://orcid.org/0000-0002-3949-1826O. S. Shpychak1https://orcid.org/0000-0002-3015-8584O. S. Kukhtenko2https://orcid.org/0000-0003-4908-6717Ye. A. Bezrukavyi3https://orcid.org/0000-0001-7527-9788H. B. Yurieva4https://orcid.org/0000-0001-9719-2122Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy, Kharkiv, UkraineInstitute for Advanced Training of Pharmacy Specialists, National University of Pharmacy, Kharkiv, UkraineNational University of Pharmacy, Kharkiv, UkraineNational University of Pharmacy, Kharkiv, UkraineNational University of Pharmacy, Kharkiv, UkraineThe aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental test samples of mixtures of the plant substance of domestic origin CPHTE with groups of excipients, approved for medical use, were used as the object of research. Results. We conducted experimental research by a mathematical planning method called the Greek–Latin square. In this study, we investigated how 16 different auxiliary substances affected the pharmacotechnological properties of tableting masses and tablets made from PPTEG with cardioprotective properties. Our goal was to determine the optimal composition and manufacturing process for a medication, specifically “Pastinocard” tablets. We also developed project plans for manufacturing regulations and quality control methods, which we successfully tested in the industrial production setting at Pharmaceutical Company “Zdorovye”, LTD in Kharkiv. Conclusions. The formulation for cardioprotective tablets, designated as “Pastinocard”, has been both theoretically justified and experimentally developed by domestic CPHTE raw materials. These research findings have been instrumental in crafting the regulatory documentation for quality control and the production processes of the resulting tablet medication.http://pharmed.zsmu.edu.ua/article/view/287001/284228parsnipsplant extractsexcipientscompositionpharmacy technologytablets |
| spellingShingle | N. А. Symonenko O. S. Shpychak O. S. Kukhtenko Ye. A. Bezrukavyi H. B. Yurieva Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki parsnips plant extracts excipients composition pharmacy technology tablets |
| title | Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets |
| title_full | Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets |
| title_fullStr | Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets |
| title_full_unstemmed | Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets |
| title_short | Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets |
| title_sort | justification of the choice of excipients during the development of the composition of pastinocard tablets |
| topic | parsnips plant extracts excipients composition pharmacy technology tablets |
| url | http://pharmed.zsmu.edu.ua/article/view/287001/284228 |
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