Insulin signaling is acutely required for long-term memory in Drosophila
Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in lo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00008/full |
| _version_ | 1819237805025394688 |
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| author | Daniel Brent Chambers Alaura eAndroschuk Cory eRosenfelt Steven eLanger Mark eHarding Francois eBolduc |
| author_facet | Daniel Brent Chambers Alaura eAndroschuk Cory eRosenfelt Steven eLanger Mark eHarding Francois eBolduc |
| author_sort | Daniel Brent Chambers |
| collection | DOAJ |
| description | Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies. |
| first_indexed | 2024-12-23T13:26:10Z |
| format | Article |
| id | doaj.art-97c5fdf1dde14f6584cc5f831949251f |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-23T13:26:10Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-97c5fdf1dde14f6584cc5f831949251f2022-12-21T17:45:19ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102015-03-01910.3389/fncir.2015.00008132538Insulin signaling is acutely required for long-term memory in DrosophilaDaniel Brent Chambers0Alaura eAndroschuk1Cory eRosenfelt2Steven eLanger3Mark eHarding4Francois eBolduc5University of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaMemory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies.http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00008/fullLearningLong-term memoryprotein synthesisInsulin receptorinsulin receptor substrate |
| spellingShingle | Daniel Brent Chambers Alaura eAndroschuk Cory eRosenfelt Steven eLanger Mark eHarding Francois eBolduc Insulin signaling is acutely required for long-term memory in Drosophila Frontiers in Neural Circuits Learning Long-term memory protein synthesis Insulin receptor insulin receptor substrate |
| title | Insulin signaling is acutely required for long-term memory in Drosophila |
| title_full | Insulin signaling is acutely required for long-term memory in Drosophila |
| title_fullStr | Insulin signaling is acutely required for long-term memory in Drosophila |
| title_full_unstemmed | Insulin signaling is acutely required for long-term memory in Drosophila |
| title_short | Insulin signaling is acutely required for long-term memory in Drosophila |
| title_sort | insulin signaling is acutely required for long term memory in drosophila |
| topic | Learning Long-term memory protein synthesis Insulin receptor insulin receptor substrate |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00008/full |
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