Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae
In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-11-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/11/4419 |
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| author | Félix V. Vega Mercedes R. Vieytes Luis M. Botana Olivier P. Thomas Henar López-Alonso Juan A. Rubiolo Eva Ternon |
| author_facet | Félix V. Vega Mercedes R. Vieytes Luis M. Botana Olivier P. Thomas Henar López-Alonso Juan A. Rubiolo Eva Ternon |
| author_sort | Félix V. Vega |
| collection | DOAJ |
| description | In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections. |
| first_indexed | 2024-04-11T22:18:26Z |
| format | Article |
| id | doaj.art-97c7a57f7b14451d92f4a68d048da04e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:18:26Z |
| publishDate | 2013-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-97c7a57f7b14451d92f4a68d048da04e2022-12-22T04:00:17ZengMDPI AGMarine Drugs1660-33972013-11-0111114419443410.3390/md11114419Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiaeFélix V. VegaMercedes R. VieytesLuis M. BotanaOlivier P. ThomasHenar López-AlonsoJuan A. RubioloEva TernonIn this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections.http://www.mdpi.com/1660-3397/11/11/4419crambescidine-816antifungalcell cycle arrestapoptosis |
| spellingShingle | Félix V. Vega Mercedes R. Vieytes Luis M. Botana Olivier P. Thomas Henar López-Alonso Juan A. Rubiolo Eva Ternon Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae Marine Drugs crambescidine-816 antifungal cell cycle arrest apoptosis |
| title | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
| title_full | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
| title_fullStr | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
| title_full_unstemmed | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
| title_short | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
| title_sort | crambescidin 816 acts as a fungicidal with more potency than crambescidin 800 and 830 inducing cell cycle arrest increased cell size and apoptosis in saccharomyces cerevisiae |
| topic | crambescidine-816 antifungal cell cycle arrest apoptosis |
| url | http://www.mdpi.com/1660-3397/11/11/4419 |
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