Tocilizumab in combination with a standard induction chemotherapy in acute myeloid leukaemia patients (TOCILAM study): a single-centre, single-arm, phase 1 trialResearch in context

Tocilizumab in combination with a standard induction chemotherapy in acute myeloid leukaemia patients (TOCILAM study): a single-centre, single-arm, phase 1 trialResearch in context

Summary: Background: In acute myeloid leukaemia (AML), interleukin-6 (IL-6) promotes chemo-resistance and its levels correlate with poor prognosis. IL-6 blockade may represent a promising therapeutic strategy. We aimed to test, tocilizumab, an anti-IL-6 receptor (R) monoclonal antibody in combinati...

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Bibliographic Details
Main Authors: Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Thierry Guillaume, Yannick Le Bris, Olivier Theisen, Marie C. Béné, Marion Eveillard, Marie Rimbert, Maxime Jullien, Lucie Planche, Joelle Gaschet, Patrice Chevallier
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:EClinicalMedicine
Subjects:
Acute myeloid leukaemia
Induction chemotherapy
IL-6
Tocilizumab
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023004315

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