Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study
Background and Purpose: Perihematomal edema (PHE) is associated with poor functional outcomes after intracerebral hemorrhage (ICH). Early identification of risk factors associated with PHE growth may allow for targeted therapeutic interventions.Methods: We used data contained in the risk stratificat...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.700166/full |
| _version_ | 1818640727179001856 |
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| author | Gengzhao Ye Shuna Huang Renlong Chen Yan Zheng Wei Huang Zhuyu Gao Lueming Cai Mingpei Zhao Ke Ma Qiu He Fuxin Lin Yuanxiang Lin Dengliang Wang Wenhua Fang Dezhi Kang Xiyue Wu |
| author_facet | Gengzhao Ye Shuna Huang Renlong Chen Yan Zheng Wei Huang Zhuyu Gao Lueming Cai Mingpei Zhao Ke Ma Qiu He Fuxin Lin Yuanxiang Lin Dengliang Wang Wenhua Fang Dezhi Kang Xiyue Wu |
| author_sort | Gengzhao Ye |
| collection | DOAJ |
| description | Background and Purpose: Perihematomal edema (PHE) is associated with poor functional outcomes after intracerebral hemorrhage (ICH). Early identification of risk factors associated with PHE growth may allow for targeted therapeutic interventions.Methods: We used data contained in the risk stratification and minimally invasive surgery in acute intracerebral hemorrhage (Risa-MIS-ICH) patients: a prospective multicenter cohort study. Patients' clinical, laboratory, and radiological data within 24 h of admission were obtained from their medical records. The absolute increase in PHE volume from baseline to day 3 was defined as iPHE volume. Poor outcome was defined as modified Rankin Scale (mRS) of 4 to 6 at 90 days. Binary logistic regression was used to assess the relationship between iPHE volume and poor outcome. The receiver operating characteristic curve was used to find the best cutoff. Linear regression was used to identify variables associated with iPHE volume (ClinicalTrials.gov Identifier: NCT03862729).Results: One hundred ninety-seven patients were included in this study. iPHE volume was significantly associated with poor outcome [P = 0.003, odds ratio (OR) 1.049, 95% confidence interval (CI) 1.016–1.082] after adjustment for hematoma volume. The best cutoff point of iPHE volume was 7.98 mL with a specificity of 71.4% and a sensitivity of 47.5%. Diabetes mellitus (P = 0.043, β = 7.66 95% CI 0.26–15.07), black hole sign (P = 0.002, β = 18.93 95% CI 6.84–31.02), and initial ICH volume (P = 0.018, β = 0.20 95% CI 0.03–0.37) were significantly associated with iPHE volume. After adjusting for hematoma expansion, the black hole sign could still independently predict the increase of PHE (P < 0.001, β = 21.62 95% CI 10.10–33.15).Conclusions: An increase of PHE volume >7.98 mL from baseline to day 3 may lead to poor outcome. Patients with diabetes mellitus, black hole sign, and large initial hematoma volume result in more PHE growth, which should garner attention in the treatment. |
| first_indexed | 2024-12-16T23:15:52Z |
| format | Article |
| id | doaj.art-97c85fe17af246b5a66dcbff53b6c463 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T23:15:52Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-97c85fe17af246b5a66dcbff53b6c4632022-12-21T22:12:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.700166700166Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH StudyGengzhao Ye0Shuna Huang1Renlong Chen2Yan Zheng3Wei Huang4Zhuyu Gao5Lueming Cai6Mingpei Zhao7Ke Ma8Qiu He9Fuxin Lin10Yuanxiang Lin11Dengliang Wang12Wenhua Fang13Dezhi Kang14Xiyue Wu15Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Clinical Research and Translation Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Clinical Research and Translation Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaBackground and Purpose: Perihematomal edema (PHE) is associated with poor functional outcomes after intracerebral hemorrhage (ICH). Early identification of risk factors associated with PHE growth may allow for targeted therapeutic interventions.Methods: We used data contained in the risk stratification and minimally invasive surgery in acute intracerebral hemorrhage (Risa-MIS-ICH) patients: a prospective multicenter cohort study. Patients' clinical, laboratory, and radiological data within 24 h of admission were obtained from their medical records. The absolute increase in PHE volume from baseline to day 3 was defined as iPHE volume. Poor outcome was defined as modified Rankin Scale (mRS) of 4 to 6 at 90 days. Binary logistic regression was used to assess the relationship between iPHE volume and poor outcome. The receiver operating characteristic curve was used to find the best cutoff. Linear regression was used to identify variables associated with iPHE volume (ClinicalTrials.gov Identifier: NCT03862729).Results: One hundred ninety-seven patients were included in this study. iPHE volume was significantly associated with poor outcome [P = 0.003, odds ratio (OR) 1.049, 95% confidence interval (CI) 1.016–1.082] after adjustment for hematoma volume. The best cutoff point of iPHE volume was 7.98 mL with a specificity of 71.4% and a sensitivity of 47.5%. Diabetes mellitus (P = 0.043, β = 7.66 95% CI 0.26–15.07), black hole sign (P = 0.002, β = 18.93 95% CI 6.84–31.02), and initial ICH volume (P = 0.018, β = 0.20 95% CI 0.03–0.37) were significantly associated with iPHE volume. After adjusting for hematoma expansion, the black hole sign could still independently predict the increase of PHE (P < 0.001, β = 21.62 95% CI 10.10–33.15).Conclusions: An increase of PHE volume >7.98 mL from baseline to day 3 may lead to poor outcome. Patients with diabetes mellitus, black hole sign, and large initial hematoma volume result in more PHE growth, which should garner attention in the treatment.https://www.frontiersin.org/articles/10.3389/fneur.2021.700166/fullintracerebral hemorrhageperihematomal edemablack hole signPHE expansionpredictors |
| spellingShingle | Gengzhao Ye Shuna Huang Renlong Chen Yan Zheng Wei Huang Zhuyu Gao Lueming Cai Mingpei Zhao Ke Ma Qiu He Fuxin Lin Yuanxiang Lin Dengliang Wang Wenhua Fang Dezhi Kang Xiyue Wu Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study Frontiers in Neurology intracerebral hemorrhage perihematomal edema black hole sign PHE expansion predictors |
| title | Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study |
| title_full | Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study |
| title_fullStr | Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study |
| title_full_unstemmed | Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study |
| title_short | Early Predictors of the Increase in Perihematomal Edema Volume After Intracerebral Hemorrhage: A Retrospective Analysis From the Risa-MIS-ICH Study |
| title_sort | early predictors of the increase in perihematomal edema volume after intracerebral hemorrhage a retrospective analysis from the risa mis ich study |
| topic | intracerebral hemorrhage perihematomal edema black hole sign PHE expansion predictors |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.700166/full |
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