The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis
Objective: The M235T polymorphism in the angiotensinogen gene has been reported to be associated with the development of atrial fibrillation (AF).However, results from observational studies are conflicting. Methods: PubMed, google scholar and China National Knowledge Infrastructure database(2000.1–2...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313513482 |
| _version_ | 1797285409052426240 |
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| author | HuiXuan Wang Yi Teng Ke Wang ZhengWu Xia YuanYuan Tian CuiJuan Li |
| author_facet | HuiXuan Wang Yi Teng Ke Wang ZhengWu Xia YuanYuan Tian CuiJuan Li |
| author_sort | HuiXuan Wang |
| collection | DOAJ |
| description | Objective: The M235T polymorphism in the angiotensinogen gene has been reported to be associated with the development of atrial fibrillation (AF).However, results from observational studies are conflicting. Methods: PubMed, google scholar and China National Knowledge Infrastructure database(2000.1–2013.4) were searched for eligible articles; four separate studies with 2580 subjects on the relationship between M235T polymorphism and AF were analyzed by meta-analysis. The associations between M235T polymorphism and AF risk were estimated by pooled odds ratio (OR) and 95% confidence interval (CI) using a fixed or random-effects model. Results: There was a significant association between M235T polymorphism and AF. The pooled OR for the recessive model in the total population was 2.17 (95% CI: 1.39–3.38, I 2 =0%). In a subgroup analysis by nationality, the pooled OR for TT vs. MM genotype was 0.55 (95% CI: 0.32–0.95, I 2 =0%) and the pooled OR for the recessive model was 1.86 (95% CI: 1.08–3.20, I 2 =0%) in Asians. Conclusions: The current meta-analysis suggested that the M235T polymorphism in the angiotensinogen gene might be related to the increased risk of AF in Asians. Conclusive evidence on the effects of the variants in AF should be addressed in further studies. |
| first_indexed | 2024-03-07T18:02:48Z |
| format | Article |
| id | doaj.art-97c89ceb5dcb4721bc1f1efc1e5328ee |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:48Z |
| publishDate | 2015-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-97c89ceb5dcb4721bc1f1efc1e5328ee2024-03-02T10:24:28ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-09-011610.1177/1470320313513482The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysisHuiXuan WangYi TengKe WangZhengWu XiaYuanYuan TianCuiJuan LiObjective: The M235T polymorphism in the angiotensinogen gene has been reported to be associated with the development of atrial fibrillation (AF).However, results from observational studies are conflicting. Methods: PubMed, google scholar and China National Knowledge Infrastructure database(2000.1–2013.4) were searched for eligible articles; four separate studies with 2580 subjects on the relationship between M235T polymorphism and AF were analyzed by meta-analysis. The associations between M235T polymorphism and AF risk were estimated by pooled odds ratio (OR) and 95% confidence interval (CI) using a fixed or random-effects model. Results: There was a significant association between M235T polymorphism and AF. The pooled OR for the recessive model in the total population was 2.17 (95% CI: 1.39–3.38, I 2 =0%). In a subgroup analysis by nationality, the pooled OR for TT vs. MM genotype was 0.55 (95% CI: 0.32–0.95, I 2 =0%) and the pooled OR for the recessive model was 1.86 (95% CI: 1.08–3.20, I 2 =0%) in Asians. Conclusions: The current meta-analysis suggested that the M235T polymorphism in the angiotensinogen gene might be related to the increased risk of AF in Asians. Conclusive evidence on the effects of the variants in AF should be addressed in further studies.https://doi.org/10.1177/1470320313513482 |
| spellingShingle | HuiXuan Wang Yi Teng Ke Wang ZhengWu Xia YuanYuan Tian CuiJuan Li The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis |
| title_full | The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis |
| title_fullStr | The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis |
| title_full_unstemmed | The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis |
| title_short | The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis |
| title_sort | m235t polymorphism in the angiotensinogen gene and atrial fibrillation a meta analysis |
| url | https://doi.org/10.1177/1470320313513482 |
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