Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease
Parkinson’s disease is a multifactorial disorder of the nervous system, the main features of which are progressive degeneration of dopaminergic neurons in the nigra pars compacta nigrostriatal tract and subsequent deficiency of the neurotransmitter dopamine in the areas of the brain, leading to the...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2020-07-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/5683 |
| _version_ | 1797841301948858368 |
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| author | A. S. Panova D. S. Dergachev M. A. Subotyalov V. D. Dergachev |
| author_facet | A. S. Panova D. S. Dergachev M. A. Subotyalov V. D. Dergachev |
| author_sort | A. S. Panova |
| collection | DOAJ |
| description | Parkinson’s disease is a multifactorial disorder of the nervous system, the main features of which are progressive degeneration of dopaminergic neurons in the nigra pars compacta nigrostriatal tract and subsequent deficiency of the neurotransmitter dopamine in the areas of the brain, leading to the loss of motor function, the emergence of non-motor symptoms, rigidity, akinesia or bradykinesia, motor block, and decline in cognitive functions. Parkinson’s disease has high prevalence throughout the world, and has no curative treatment in modern medicine. The available drugs such as anticholinergics, levodopa and a DOPA-decarboxylase inhibitor provide symptomatic relief only. Although dopaminergic therapy is the standard treatment of motor disabilities associated with Parkinson’s disease, it does not managed all the aspects of the disease. For this reason, the increasing numbers of patients are looking for more holistic approach to the treatment of this disease. Mucuna pruriens L. – an annual self-pollinating legume plant, can be considered as a potential complementary therapy for patients with Parkinson’s disease, as it is an extremely rich source of levodopa. Numerous studies have shown that Mucuna pruriens extracts restore biochemical and behavioral abnormalities in animals with the experimental model of Parkinson’s disease. The plant also demonstrates some antioxidant activity. The clinical effects of high-dose Mucuna pruriens are similar to levodopa, but have a more favorable tolerance profile. If long-term use of Mucuna pruriens proves safe and effective in controlled clinical trials, it could become a sustainable complementary therapy for the treatment of Parkinson’s disease, especially in low-income countries. |
| first_indexed | 2024-04-09T16:28:49Z |
| format | Article |
| id | doaj.art-97c8eb5c93c24671b4db97b012c149f8 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:28:49Z |
| publishDate | 2020-07-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-97c8eb5c93c24671b4db97b012c149f82023-04-23T06:57:12ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902020-07-0108828710.21518/2079-701X-2020-8-82-875165Review of Mucuna pruriens L. therapeutic potential for Parkinson’s diseaseA. S. Panova0D. S. Dergachev1M. A. Subotyalov2V. D. Dergachev3Novosibirsk State Pedagogical UniversityMedical SystemsNovosibirsk State Pedagogical UniversityV.M. Bekhterev National Research Medical Center for Psychiatry and NeurologyParkinson’s disease is a multifactorial disorder of the nervous system, the main features of which are progressive degeneration of dopaminergic neurons in the nigra pars compacta nigrostriatal tract and subsequent deficiency of the neurotransmitter dopamine in the areas of the brain, leading to the loss of motor function, the emergence of non-motor symptoms, rigidity, akinesia or bradykinesia, motor block, and decline in cognitive functions. Parkinson’s disease has high prevalence throughout the world, and has no curative treatment in modern medicine. The available drugs such as anticholinergics, levodopa and a DOPA-decarboxylase inhibitor provide symptomatic relief only. Although dopaminergic therapy is the standard treatment of motor disabilities associated with Parkinson’s disease, it does not managed all the aspects of the disease. For this reason, the increasing numbers of patients are looking for more holistic approach to the treatment of this disease. Mucuna pruriens L. – an annual self-pollinating legume plant, can be considered as a potential complementary therapy for patients with Parkinson’s disease, as it is an extremely rich source of levodopa. Numerous studies have shown that Mucuna pruriens extracts restore biochemical and behavioral abnormalities in animals with the experimental model of Parkinson’s disease. The plant also demonstrates some antioxidant activity. The clinical effects of high-dose Mucuna pruriens are similar to levodopa, but have a more favorable tolerance profile. If long-term use of Mucuna pruriens proves safe and effective in controlled clinical trials, it could become a sustainable complementary therapy for the treatment of Parkinson’s disease, especially in low-income countries.https://www.med-sovet.pro/jour/article/view/5683parkinson diseasemucuna prurienslevodopaaurvedaphytotherapy |
| spellingShingle | A. S. Panova D. S. Dergachev M. A. Subotyalov V. D. Dergachev Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease Медицинский совет parkinson disease mucuna pruriens levodopa aurveda phytotherapy |
| title | Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease |
| title_full | Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease |
| title_fullStr | Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease |
| title_full_unstemmed | Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease |
| title_short | Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease |
| title_sort | review of mucuna pruriens l therapeutic potential for parkinson s disease |
| topic | parkinson disease mucuna pruriens levodopa aurveda phytotherapy |
| url | https://www.med-sovet.pro/jour/article/view/5683 |
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