Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study
ABSTRACT Objective: To investigate the association between plasma Hydrogen Sulfide (H2S) levels and visceral fat area (VFA) among Chinese young men. Subjects and methods: This cross-sectional study involved 156 Chinese male subjects, aged 18–45 years, who visited the First Hospital of Qinhuangdao...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2021-03-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300269&tlng=en |
| _version_ | 1798022196760674304 |
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| author | Dongmei Fan Huiyan Huang Xing Wang Junru Liu Bowei Liu Fuzai Yin |
| author_facet | Dongmei Fan Huiyan Huang Xing Wang Junru Liu Bowei Liu Fuzai Yin |
| author_sort | Dongmei Fan |
| collection | DOAJ |
| description | ABSTRACT Objective: To investigate the association between plasma Hydrogen Sulfide (H2S) levels and visceral fat area (VFA) among Chinese young men. Subjects and methods: This cross-sectional study involved 156 Chinese male subjects, aged 18–45 years, who visited the First Hospital of Qinhuangdao (Hebei, China) in 2014 for annual health check-up. Participants were categorized into: low (VFA < 75.57 cm2), medium (75.57 cm2 ≤ VFA<100.37 cm2), and high (VFA ≥ 100.37 cm2) (n = 52/group). We estimated VFA and plasma H2S levels by using bioelectrical impedance analysis and a fluorescence probe-based approach, respectively. The associations of H2S with VFA and obesity anthropometric measures were assessed. Results: In the high VFA group, the body mass index (BMI, 30.4 ± 2.45 kg/m2), total body fat (TBF, 27.9 ± 3.23 kg), plasma H2S (3.5 μmol/L), free fatty acid (FFA, 0.6 ± 0.24 mmol/L), triglyceride (TG, 2.0 mmol/L), and total cholesterol (TC, 5.5 ± 1.02 mmol/L) levels were significantly higher than that of those of the low and medium VFA groups, respectively (P < 0.05). Plasma H2S levels were found to be inversely correlated with VFA, TBF, waist circumference, BMI, FFA, LnFINS, LnHOMA-IR, LnTG, TC, and LDL-C (P < 0.05). Multiple backward stepwise regression analysis revealed an inverse correlation of plasma H2S levels with FFA (β = −0.214, P = 0.005) and VFA (β = −0.429, P < 0.001), independent of adiposity measures and other confounding factors. Conclusion: VFA was independently and inversely associated with plasma H2S levels among Chinese young men. Therefore, determining plasma H2S levels could aid in the assessment of abnormal VAT distribution. |
| first_indexed | 2024-04-11T17:25:56Z |
| format | Article |
| id | doaj.art-97c9c920165c4d418c4d3b1cb9b8ad19 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T17:25:56Z |
| publishDate | 2021-03-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-97c9c920165c4d418c4d3b1cb9b8ad192022-12-22T04:12:19ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922021-03-0165326927610.20945/2359-3997000000339Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional studyDongmei Fanhttps://orcid.org/0000-0002-5775-276XHuiyan Huanghttps://orcid.org/0000-0002-8172-7097Xing Wanghttps://orcid.org/0000-0003-0519-3238Junru Liuhttps://orcid.org/0000-0002-7825-6183Bowei Liuhttps://orcid.org/0000-0002-4936-2358Fuzai Yinhttps://orcid.org/0000-0002-7518-5906ABSTRACT Objective: To investigate the association between plasma Hydrogen Sulfide (H2S) levels and visceral fat area (VFA) among Chinese young men. Subjects and methods: This cross-sectional study involved 156 Chinese male subjects, aged 18–45 years, who visited the First Hospital of Qinhuangdao (Hebei, China) in 2014 for annual health check-up. Participants were categorized into: low (VFA < 75.57 cm2), medium (75.57 cm2 ≤ VFA<100.37 cm2), and high (VFA ≥ 100.37 cm2) (n = 52/group). We estimated VFA and plasma H2S levels by using bioelectrical impedance analysis and a fluorescence probe-based approach, respectively. The associations of H2S with VFA and obesity anthropometric measures were assessed. Results: In the high VFA group, the body mass index (BMI, 30.4 ± 2.45 kg/m2), total body fat (TBF, 27.9 ± 3.23 kg), plasma H2S (3.5 μmol/L), free fatty acid (FFA, 0.6 ± 0.24 mmol/L), triglyceride (TG, 2.0 mmol/L), and total cholesterol (TC, 5.5 ± 1.02 mmol/L) levels were significantly higher than that of those of the low and medium VFA groups, respectively (P < 0.05). Plasma H2S levels were found to be inversely correlated with VFA, TBF, waist circumference, BMI, FFA, LnFINS, LnHOMA-IR, LnTG, TC, and LDL-C (P < 0.05). Multiple backward stepwise regression analysis revealed an inverse correlation of plasma H2S levels with FFA (β = −0.214, P = 0.005) and VFA (β = −0.429, P < 0.001), independent of adiposity measures and other confounding factors. Conclusion: VFA was independently and inversely associated with plasma H2S levels among Chinese young men. Therefore, determining plasma H2S levels could aid in the assessment of abnormal VAT distribution.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300269&tlng=enHydrogen sulfidevisceral fatcorrelation studybioelectrical impedancefree fatty acids |
| spellingShingle | Dongmei Fan Huiyan Huang Xing Wang Junru Liu Bowei Liu Fuzai Yin Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study Archives of Endocrinology and Metabolism Hydrogen sulfide visceral fat correlation study bioelectrical impedance free fatty acids |
| title | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study |
| title_full | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study |
| title_fullStr | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study |
| title_full_unstemmed | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study |
| title_short | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study |
| title_sort | inverse association of plasma hydrogen sulfide levels with visceral fat area among chinese young men a cross sectional study |
| topic | Hydrogen sulfide visceral fat correlation study bioelectrical impedance free fatty acids |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300269&tlng=en |
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