Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases

Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases

Programmable nucleases, such as zinc finger nucleases (ZFNs), transcription activator like effector nucleases (TALENs), and clustered regularly interspersed short palindromic repeats associated protein-9 (CRISPR-Cas9), hold tremendous potential for applications in the clinical setting to treat genet...

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Bibliographic Details
Main Authors: Kentaro Ishida, Peter Gee, Akitsu Hotta
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR Cas9
genome editing
mutagenesis
off-target effect
Online Access:http://www.mdpi.com/1422-0067/16/10/24751

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