Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy
Objectives: To evaluate sensory electrophysiology, terminal latency index (TLI), and treatment response in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: We performed a retrospective review of 147 patients with CIDP who underwent electrodiagnostic...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Clinical Neurophysiology Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X19300319 |
| _version_ | 1818859011618897920 |
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| author | Anza B. Memon Sarah Madani Bashiruddin K. Ahmad Kavita Grover Ximena Arcila-londono Lonni Schultz Naganand Sripathi |
| author_facet | Anza B. Memon Sarah Madani Bashiruddin K. Ahmad Kavita Grover Ximena Arcila-londono Lonni Schultz Naganand Sripathi |
| author_sort | Anza B. Memon |
| collection | DOAJ |
| description | Objectives: To evaluate sensory electrophysiology, terminal latency index (TLI), and treatment response in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: We performed a retrospective review of 147 patients with CIDP who underwent electrodiagnostic evaluation (January 2000–December 2015). Eighty-nine patients fulfilled electrophysiological criteria described by the Ad hoc Subcommittee of the American Academy of Neurology and Albers et al. Fifty-eight patients were divided into idiopathic (N = 40) and diabetic (N = 18) groups. These groups were compared for age, sex, cerebrospinal fluid protein, response to treatment, sensory response abnormalities, and TLI measurements using chi-square tests for binary and categorical variables and using t-tests and mixed-effects models for continuous variables. Results: The difference in abnormal rates of sensory responses was significant for the sural nerve, with the idiopathic group having a lower rate than the diabetic group (80% vs. 100%, p < 0.001). No group differences in the TLI measurements were significant. Conclusions: Sural sensory responses may have some value in differentiating idiopathic CIDP from diabetic CIDP. Larger prospective studies are needed to confirm our findings. Significance: Our study suggests that abnormal sural sensory potentials may have some significance in differentiating idiopathic CIDP from diabetic CIDP. Keywords: Terminal latency index, Sensory electrophysiology, CIDP, Nerve conduction study, Sensory nerve action potential, Myelin-associated glycoprotein |
| first_indexed | 2024-12-19T09:05:24Z |
| format | Article |
| id | doaj.art-97cc97e2e71e40ada6036d98740b3a16 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-12-19T09:05:24Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-97cc97e2e71e40ada6036d98740b3a162022-12-21T20:28:21ZengElsevierClinical Neurophysiology Practice2467-981X2019-01-014190193Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathyAnza B. Memon0Sarah Madani1Bashiruddin K. Ahmad2Kavita Grover3Ximena Arcila-londono4Lonni Schultz5Naganand Sripathi6Department of Neurology, Henry Ford Health System, Detroit, MI, USA; Wayne State University, School of Medicine, Detroit, MI, USA; Corresponding author at: 2799 W Grand Blvd, Detroit, Michigan 48202, USA.Department of Neurology, Henry Ford Health System, Detroit, MI, USADepartment of Neurology, Henry Ford Health System, Detroit, MI, USADepartment of Neurology, Henry Ford Health System, Detroit, MI, USA; Wayne State University, School of Medicine, Detroit, MI, USADepartment of Neurology, Henry Ford Health System, Detroit, MI, USA; Wayne State University, School of Medicine, Detroit, MI, USADepartment of Neurology, Henry Ford Health System, Detroit, MI, USADepartment of Neurology, Henry Ford Health System, Detroit, MI, USA; Wayne State University, School of Medicine, Detroit, MI, USAObjectives: To evaluate sensory electrophysiology, terminal latency index (TLI), and treatment response in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: We performed a retrospective review of 147 patients with CIDP who underwent electrodiagnostic evaluation (January 2000–December 2015). Eighty-nine patients fulfilled electrophysiological criteria described by the Ad hoc Subcommittee of the American Academy of Neurology and Albers et al. Fifty-eight patients were divided into idiopathic (N = 40) and diabetic (N = 18) groups. These groups were compared for age, sex, cerebrospinal fluid protein, response to treatment, sensory response abnormalities, and TLI measurements using chi-square tests for binary and categorical variables and using t-tests and mixed-effects models for continuous variables. Results: The difference in abnormal rates of sensory responses was significant for the sural nerve, with the idiopathic group having a lower rate than the diabetic group (80% vs. 100%, p < 0.001). No group differences in the TLI measurements were significant. Conclusions: Sural sensory responses may have some value in differentiating idiopathic CIDP from diabetic CIDP. Larger prospective studies are needed to confirm our findings. Significance: Our study suggests that abnormal sural sensory potentials may have some significance in differentiating idiopathic CIDP from diabetic CIDP. Keywords: Terminal latency index, Sensory electrophysiology, CIDP, Nerve conduction study, Sensory nerve action potential, Myelin-associated glycoproteinhttp://www.sciencedirect.com/science/article/pii/S2467981X19300319 |
| spellingShingle | Anza B. Memon Sarah Madani Bashiruddin K. Ahmad Kavita Grover Ximena Arcila-londono Lonni Schultz Naganand Sripathi Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy Clinical Neurophysiology Practice |
| title | Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| title_full | Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| title_fullStr | Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| title_full_unstemmed | Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| title_short | Value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| title_sort | value of terminal latency index and sensory electrophysiology in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X19300319 |
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