P53 orchestrates a complex symphony of cellular processes during oncosuppression
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1852066 |
| _version_ | 1827809355936825344 |
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| author | Liz J. Valente Laura D. Attardi |
| author_facet | Liz J. Valente Laura D. Attardi |
| author_sort | Liz J. Valente |
| collection | DOAJ |
| description | We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the TP53 (tumor protein p53) gene is so prevalent in human cancers. |
| first_indexed | 2024-03-11T22:40:03Z |
| format | Article |
| id | doaj.art-97cd1f591c234a7fb3f506ccefb827f3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:03Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-97cd1f591c234a7fb3f506ccefb827f32023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-01-018110.1080/23723556.2020.18520661852066P53 orchestrates a complex symphony of cellular processes during oncosuppressionLiz J. Valente0Laura D. Attardi1Stanford University School of MedicineStanford University School of MedicineWe recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the TP53 (tumor protein p53) gene is so prevalent in human cancers.http://dx.doi.org/10.1080/23723556.2020.1852066p53tumor suppressiontransformationcancercell biology |
| spellingShingle | Liz J. Valente Laura D. Attardi P53 orchestrates a complex symphony of cellular processes during oncosuppression Molecular & Cellular Oncology p53 tumor suppression transformation cancer cell biology |
| title | P53 orchestrates a complex symphony of cellular processes during oncosuppression |
| title_full | P53 orchestrates a complex symphony of cellular processes during oncosuppression |
| title_fullStr | P53 orchestrates a complex symphony of cellular processes during oncosuppression |
| title_full_unstemmed | P53 orchestrates a complex symphony of cellular processes during oncosuppression |
| title_short | P53 orchestrates a complex symphony of cellular processes during oncosuppression |
| title_sort | p53 orchestrates a complex symphony of cellular processes during oncosuppression |
| topic | p53 tumor suppression transformation cancer cell biology |
| url | http://dx.doi.org/10.1080/23723556.2020.1852066 |
| work_keys_str_mv | AT lizjvalente p53orchestratesacomplexsymphonyofcellularprocessesduringoncosuppression AT lauradattardi p53orchestratesacomplexsymphonyofcellularprocessesduringoncosuppression |