ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019
Aim: Secondary bloodstream infections (SBSIs) are caused by another infection and differ from primary bloodstream infections (PBSIs) in terms of prevention and treatment strategies. The aim of this study was to determine the risk factors for bloodstream infections which were secondary to the most co...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | deu |
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German Medical Science GMS Publishing House
2022-04-01
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| Series: | GMS Hygiene and Infection Control |
| Subjects: | |
| Online Access: | http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000408.shtml |
| _version_ | 1818670370952052736 |
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| author | Hekimoglu, Can Huseyin Yildiz, Serap Suzuk Sahan, Selda Batir, Esen Yildirim Gozel, Emine Altun, Dilek Pehlivanturk, Gulen Comce, Muhammet Kara, Fatih |
| author_facet | Hekimoglu, Can Huseyin Yildiz, Serap Suzuk Sahan, Selda Batir, Esen Yildirim Gozel, Emine Altun, Dilek Pehlivanturk, Gulen Comce, Muhammet Kara, Fatih |
| author_sort | Hekimoglu, Can Huseyin |
| collection | DOAJ |
| description | Aim: Secondary bloodstream infections (SBSIs) are caused by another infection and differ from primary bloodstream infections (PBSIs) in terms of prevention and treatment strategies. The aim of this study was to determine the risk factors for bloodstream infections which were secondary to the most common healthcare-associated infections caused by the most common microorganisms in intensive care units (ICUs) and to examine whether extended-spectrum beta lactamase (ESBL) production and carbapenem resistance is related to the higher risk or not.Methods: The study population consisted of patients in ICUs with ventilator-associated pneumonia (VAP), ventilator-associated event (VAE) or catheter-associated urinary tract infection (CAUTI) caused by or between 2014 and 2019. The data were obtained through the National Healthcare-associated Infections Surveillance Network. Multivariate logistic regression analysis was performed separately for VAP/VAE and CAUTI to determine the risk factors for the development of SBSI.Results: Microorganism, ICU type, bed capasity and carbapenem resistance were found to be risk factors for SBSI for both types of infection. For VAPs/VAEs, female gender and hospital type were also identified as risk factors. The highest risk was in and in emergency ICUs. Among the hospitals, the highest risk in VAPs/VAEs was found in government education and research hospitals. ESBL production for . and increased the risk in patients with VAP/VAE; however, it did not increase in patients with CAUTI.Discussion: By using the risk factors, it may be possible to recognize SBSIs earlier, especially in patients with CAUTIs or VAPs/VAEs caused by carbapenem-resistant or ESBL-producing . |
| first_indexed | 2024-12-17T07:07:02Z |
| format | Article |
| id | doaj.art-97cd6f3d1a0e406eba66259e11930a67 |
| institution | Directory Open Access Journal |
| issn | 2196-5226 |
| language | deu |
| last_indexed | 2024-12-17T07:07:02Z |
| publishDate | 2022-04-01 |
| publisher | German Medical Science GMS Publishing House |
| record_format | Article |
| series | GMS Hygiene and Infection Control |
| spelling | doaj.art-97cd6f3d1a0e406eba66259e11930a672022-12-21T21:59:08ZdeuGerman Medical Science GMS Publishing HouseGMS Hygiene and Infection Control2196-52262022-04-0117Doc0510.3205/dgkh000408ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019Hekimoglu, Can Huseyin0Yildiz, Serap Suzuk1Sahan, Selda2Batir, Esen3Yildirim Gozel, Emine4Altun, Dilek5Pehlivanturk, Gulen6Comce, Muhammet7Kara, Fatih8Ministry of Health, General Directorate of Public Health, Department of Communicable Diseases, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Microbiology Reference Laboratory and Biological Products, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Tuberculosis, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Communicable Diseases, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Communicable Diseases, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Communicable Diseases, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Department of Communicable Diseases, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Ankara, TurkeyMinistry of Health, General Directorate of Public Health, Ankara, TurkeyAim: Secondary bloodstream infections (SBSIs) are caused by another infection and differ from primary bloodstream infections (PBSIs) in terms of prevention and treatment strategies. The aim of this study was to determine the risk factors for bloodstream infections which were secondary to the most common healthcare-associated infections caused by the most common microorganisms in intensive care units (ICUs) and to examine whether extended-spectrum beta lactamase (ESBL) production and carbapenem resistance is related to the higher risk or not.Methods: The study population consisted of patients in ICUs with ventilator-associated pneumonia (VAP), ventilator-associated event (VAE) or catheter-associated urinary tract infection (CAUTI) caused by or between 2014 and 2019. The data were obtained through the National Healthcare-associated Infections Surveillance Network. Multivariate logistic regression analysis was performed separately for VAP/VAE and CAUTI to determine the risk factors for the development of SBSI.Results: Microorganism, ICU type, bed capasity and carbapenem resistance were found to be risk factors for SBSI for both types of infection. For VAPs/VAEs, female gender and hospital type were also identified as risk factors. The highest risk was in and in emergency ICUs. Among the hospitals, the highest risk in VAPs/VAEs was found in government education and research hospitals. ESBL production for . and increased the risk in patients with VAP/VAE; however, it did not increase in patients with CAUTI.Discussion: By using the risk factors, it may be possible to recognize SBSIs earlier, especially in patients with CAUTIs or VAPs/VAEs caused by carbapenem-resistant or ESBL-producing .http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000408.shtmlsecondary bloodstream infectioncatheter-associated urinary tract infectionventilator-associated pneumoniaventilator-associated eventcarbapenem resistanceextended spectrum beta-lactamase |
| spellingShingle | Hekimoglu, Can Huseyin Yildiz, Serap Suzuk Sahan, Selda Batir, Esen Yildirim Gozel, Emine Altun, Dilek Pehlivanturk, Gulen Comce, Muhammet Kara, Fatih ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 GMS Hygiene and Infection Control secondary bloodstream infection catheter-associated urinary tract infection ventilator-associated pneumonia ventilator-associated event carbapenem resistance extended spectrum beta-lactamase |
| title | ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 |
| title_full | ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 |
| title_fullStr | ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 |
| title_full_unstemmed | ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 |
| title_short | ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014–2019 |
| title_sort | esbl production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in turkey 2014 2019 |
| topic | secondary bloodstream infection catheter-associated urinary tract infection ventilator-associated pneumonia ventilator-associated event carbapenem resistance extended spectrum beta-lactamase |
| url | http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000408.shtml |
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