Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes

Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes

Osteoporosis is mainly characterized by low bone mineral density (BMD) and is an increasingly serious public health concern. DNA methylation is a major epigenetic mechanism that may contribute to the variation in BMD and may mediate the effects of genetic and environmental factors of osteoporosis. I...

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Bibliographic Details
Main Authors: Fangtang Yu, Chuan Qiu, Chao Xu, Qing Tian, Lan-Juan Zhao, Li Wu, Hong-Wen Deng, Hui Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
osteoporosis
bone mineral density
causal inference
Mendelian randomization
DNA methylation
epigenome-wide association
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00060/full

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