Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

Abstract Background Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNV...

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Bibliographic Details
Main Authors: Yanding Zhao, Robert Carter, Sivaraman Natarajan, Frederick S. Varn, Duane A. Compton, Charles Gawad, Chao Cheng, Kristina M. Godek
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Genomics
Subjects:
Glioblastoma
Cancer stem cells
CSCs
Chromosomal instability
CIN
Aneuploidy
Online Access:http://link.springer.com/article/10.1186/s12920-019-0532-5

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