Molecular diagnostic technologies for COVID-19: Limitations and challenges
Background: To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the world needs diagnostic systems capable of rapid detection and quantification of the novel coronavirus (SARS-CoV-2). Many biomedical companies are rising to the challenge and developing COVID-19 diagnostics. In th...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123220301788 |
| _version_ | 1818992224811089920 |
|---|---|
| author | Adeel Afzal |
| author_facet | Adeel Afzal |
| author_sort | Adeel Afzal |
| collection | DOAJ |
| description | Background: To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the world needs diagnostic systems capable of rapid detection and quantification of the novel coronavirus (SARS-CoV-2). Many biomedical companies are rising to the challenge and developing COVID-19 diagnostics. In the last few months, some of these diagnostics have become commercially available for healthcare workers and clinical laboratories. However, the diagnostic technologies have specific limitations and reported several false-positive and false-negative cases, especially during the early stages of infection. Aim: This article aims to review recent developments in the field of COVID-19 diagnostics based on molecular technologies and analyze their clinical performance data. Key Concepts: The literature survey and performance-based analysis of the commercial and pre-commercial molecular diagnostics address several questions and issues related to the limitations of current technologies and highlight future research and development challenges to enable timely, rapid, low-cost, and accurate diagnosis of emerging infectious diseases. |
| first_indexed | 2024-12-20T20:22:46Z |
| format | Article |
| id | doaj.art-97cfea0ff9ca4e10b2eb3cebe612350e |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-20T20:22:46Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-97cfea0ff9ca4e10b2eb3cebe612350e2022-12-21T19:27:32ZengElsevierJournal of Advanced Research2090-12322020-11-0126149159Molecular diagnostic technologies for COVID-19: Limitations and challengesAdeel Afzal0Department of Chemistry, College of Science, University of Hafr Al Batin, PO Box 1803, Hafr Al Batin 39524, Saudi ArabiaBackground: To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the world needs diagnostic systems capable of rapid detection and quantification of the novel coronavirus (SARS-CoV-2). Many biomedical companies are rising to the challenge and developing COVID-19 diagnostics. In the last few months, some of these diagnostics have become commercially available for healthcare workers and clinical laboratories. However, the diagnostic technologies have specific limitations and reported several false-positive and false-negative cases, especially during the early stages of infection. Aim: This article aims to review recent developments in the field of COVID-19 diagnostics based on molecular technologies and analyze their clinical performance data. Key Concepts: The literature survey and performance-based analysis of the commercial and pre-commercial molecular diagnostics address several questions and issues related to the limitations of current technologies and highlight future research and development challenges to enable timely, rapid, low-cost, and accurate diagnosis of emerging infectious diseases.http://www.sciencedirect.com/science/article/pii/S2090123220301788COVID-19Clinical sensitivityIn vitro diagnosticsReal-time RT-PCRPoint-of-careSARS-CoV-2 |
| spellingShingle | Adeel Afzal Molecular diagnostic technologies for COVID-19: Limitations and challenges Journal of Advanced Research COVID-19 Clinical sensitivity In vitro diagnostics Real-time RT-PCR Point-of-care SARS-CoV-2 |
| title | Molecular diagnostic technologies for COVID-19: Limitations and challenges |
| title_full | Molecular diagnostic technologies for COVID-19: Limitations and challenges |
| title_fullStr | Molecular diagnostic technologies for COVID-19: Limitations and challenges |
| title_full_unstemmed | Molecular diagnostic technologies for COVID-19: Limitations and challenges |
| title_short | Molecular diagnostic technologies for COVID-19: Limitations and challenges |
| title_sort | molecular diagnostic technologies for covid 19 limitations and challenges |
| topic | COVID-19 Clinical sensitivity In vitro diagnostics Real-time RT-PCR Point-of-care SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2090123220301788 |
| work_keys_str_mv | AT adeelafzal moleculardiagnostictechnologiesforcovid19limitationsandchallenges |