Application of 3D bioprinting in the prevention and the therapy for human diseases

Abstract Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional...

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Main Authors: Hee-Gyeong Yi, Hyeonji Kim, Junyoung Kwon, Yeong-Jin Choi, Jinah Jang, Dong-Woo Cho
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00566-8
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author Hee-Gyeong Yi
Hyeonji Kim
Junyoung Kwon
Yeong-Jin Choi
Jinah Jang
Dong-Woo Cho
author_facet Hee-Gyeong Yi
Hyeonji Kim
Junyoung Kwon
Yeong-Jin Choi
Jinah Jang
Dong-Woo Cho
author_sort Hee-Gyeong Yi
collection DOAJ
description Abstract Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.
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spelling doaj.art-97d3446279db45859a331b482e80975d2022-12-21T22:12:20ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-05-016111710.1038/s41392-021-00566-8Application of 3D bioprinting in the prevention and the therapy for human diseasesHee-Gyeong Yi0Hyeonji Kim1Junyoung Kwon2Yeong-Jin Choi3Jinah Jang4Dong-Woo Cho5Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National UniversityDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH)Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH)Department of Advanced Biomaterials Research, Korea Institute of Materials Science (KIMS)Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH)Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH)Abstract Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.https://doi.org/10.1038/s41392-021-00566-8
spellingShingle Hee-Gyeong Yi
Hyeonji Kim
Junyoung Kwon
Yeong-Jin Choi
Jinah Jang
Dong-Woo Cho
Application of 3D bioprinting in the prevention and the therapy for human diseases
Signal Transduction and Targeted Therapy
title Application of 3D bioprinting in the prevention and the therapy for human diseases
title_full Application of 3D bioprinting in the prevention and the therapy for human diseases
title_fullStr Application of 3D bioprinting in the prevention and the therapy for human diseases
title_full_unstemmed Application of 3D bioprinting in the prevention and the therapy for human diseases
title_short Application of 3D bioprinting in the prevention and the therapy for human diseases
title_sort application of 3d bioprinting in the prevention and the therapy for human diseases
url https://doi.org/10.1038/s41392-021-00566-8
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