Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.

Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.

Macrophage infiltration is a negative prognostic factor for most cancers but gastrointestinal tumors seem to be an exception. The effect of macrophages on cancer progression depends on their phenotype, which may vary between M1 (pro-inflammatory, defensive) to M2 (tolerogenic, pro-tumoral). Gastroin...

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Main Authors: Carlos Hernández, María Dolores Barrachina, Jesús Cosín-Roger, Dolores Ortiz-Masiá, Ángeles Álvarez, Liria Terrádez, María Jesús Nicolau, Rafael Alós, Juan Vicente Esplugues, Sara Calatayud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4047028?pdf=render

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