Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases
Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/10/1/45 |
| _version_ | 1827372226020638720 |
|---|---|
| author | Kamil Sghier Maja Mur Francisco Veiga Ana Cláudia Paiva-Santos Patrícia C. Pires |
| author_facet | Kamil Sghier Maja Mur Francisco Veiga Ana Cláudia Paiva-Santos Patrícia C. Pires |
| author_sort | Kamil Sghier |
| collection | DOAJ |
| description | Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel topical and transdermal platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding the development of nanoemulgels for skin application, encapsulating a wide variety of molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed marketed drugs (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), and other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), for wound healing, skin and skin appendage infections, skin inflammatory diseases, skin cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, drug release, and drug permeation and/or retention capacity, having more advantageous characteristics than current marketed formulations. In vitro and/or in vivo studies established the safety and efficacy of the developed formulations, confirming their therapeutic potential, and making them promising platforms for the replacement of current therapies, or as possible adjuvant treatments, which might someday effectively reach the market to help fight highly incident skin or systemic diseases and conditions. |
| first_indexed | 2024-03-08T10:54:25Z |
| format | Article |
| id | doaj.art-97da73139f7745c9af63fad00dfd4efe |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-08T10:54:25Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-97da73139f7745c9af63fad00dfd4efe2024-01-26T16:39:42ZengMDPI AGGels2310-28612024-01-011014510.3390/gels10010045Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin DiseasesKamil Sghier0Maja Mur1Francisco Veiga2Ana Cláudia Paiva-Santos3Patrícia C. Pires4Faculty of Pharmacy, Masaryk University, Palackého tř. 1946, Brno-Královo Pole, 612 00 Brno, Czech RepublicFaculty of Pharmacy, University of Ljubljana, Aškerčeva c. 7, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalTopical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel topical and transdermal platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding the development of nanoemulgels for skin application, encapsulating a wide variety of molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed marketed drugs (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), and other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), for wound healing, skin and skin appendage infections, skin inflammatory diseases, skin cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, drug release, and drug permeation and/or retention capacity, having more advantageous characteristics than current marketed formulations. In vitro and/or in vivo studies established the safety and efficacy of the developed formulations, confirming their therapeutic potential, and making them promising platforms for the replacement of current therapies, or as possible adjuvant treatments, which might someday effectively reach the market to help fight highly incident skin or systemic diseases and conditions.https://www.mdpi.com/2310-2861/10/1/45anti-agingnanoemulgelsnanoemulsionsneuropathyskin cancerskin infection |
| spellingShingle | Kamil Sghier Maja Mur Francisco Veiga Ana Cláudia Paiva-Santos Patrícia C. Pires Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases Gels anti-aging nanoemulgels nanoemulsions neuropathy skin cancer skin infection |
| title | Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases |
| title_full | Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases |
| title_fullStr | Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases |
| title_full_unstemmed | Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases |
| title_short | Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases |
| title_sort | novel therapeutic hybrid systems using hydrogels and nanotechnology a focus on nanoemulgels for the treatment of skin diseases |
| topic | anti-aging nanoemulgels nanoemulsions neuropathy skin cancer skin infection |
| url | https://www.mdpi.com/2310-2861/10/1/45 |
| work_keys_str_mv | AT kamilsghier noveltherapeutichybridsystemsusinghydrogelsandnanotechnologyafocusonnanoemulgelsforthetreatmentofskindiseases AT majamur noveltherapeutichybridsystemsusinghydrogelsandnanotechnologyafocusonnanoemulgelsforthetreatmentofskindiseases AT franciscoveiga noveltherapeutichybridsystemsusinghydrogelsandnanotechnologyafocusonnanoemulgelsforthetreatmentofskindiseases AT anaclaudiapaivasantos noveltherapeutichybridsystemsusinghydrogelsandnanotechnologyafocusonnanoemulgelsforthetreatmentofskindiseases AT patriciacpires noveltherapeutichybridsystemsusinghydrogelsandnanotechnologyafocusonnanoemulgelsforthetreatmentofskindiseases |