Cardiovascular diseases and osteoporosis: What is common?
The review analyzes the possible effect of cardiac drugs on the course of osteoporosis (OP). The fact that atherosclerosis and OP share the mechanisms of development, among which the enhanced activity of the sympathetic part of the autonomic nervous system and endothelial dysfunction are most import...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2014-05-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31540 |
| _version_ | 1811208935392149504 |
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| author | I L Fedorchenko D V Nebieridze A S Safarian I A Skripnikova K E Sobchenko |
| author_facet | I L Fedorchenko D V Nebieridze A S Safarian I A Skripnikova K E Sobchenko |
| author_sort | I L Fedorchenko |
| collection | DOAJ |
| description | The review analyzes the possible effect of cardiac drugs on the course of osteoporosis (OP). The fact that atherosclerosis and OP share the mechanisms of development, among which the enhanced activity of the sympathetic part of the autonomic nervous system and endothelial dysfunction are most important, is beyond question now. In this connection, Β-adrenoblockers, nebivolol in particular, attract attention. Nebivolol is known to be a selective Β1-adrenoblocker that has an additional vasodilator property, by stimulating the synthesis of nitric oxide. This may serve to increase bone mineral density and slow down the progression of OP. At the same time, most investigations in this area are retrospective therefore fina/CONCLUSION: call for randomized prospective studies that will be able to evaluate more objectively the effect of cardiac drugs on the prevention of OP or its progression delay. |
| first_indexed | 2024-04-12T04:31:25Z |
| format | Article |
| id | doaj.art-97dc30e406b5473d9c003a7964cf08cb |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T04:31:25Z |
| publishDate | 2014-05-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-97dc30e406b5473d9c003a7964cf08cb2022-12-22T03:47:56Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422014-05-0186511611928556Cardiovascular diseases and osteoporosis: What is common?I L FedorchenkoD V NebieridzeA S SafarianI A SkripnikovaK E SobchenkoThe review analyzes the possible effect of cardiac drugs on the course of osteoporosis (OP). The fact that atherosclerosis and OP share the mechanisms of development, among which the enhanced activity of the sympathetic part of the autonomic nervous system and endothelial dysfunction are most important, is beyond question now. In this connection, Β-adrenoblockers, nebivolol in particular, attract attention. Nebivolol is known to be a selective Β1-adrenoblocker that has an additional vasodilator property, by stimulating the synthesis of nitric oxide. This may serve to increase bone mineral density and slow down the progression of OP. At the same time, most investigations in this area are retrospective therefore fina/CONCLUSION: call for randomized prospective studies that will be able to evaluate more objectively the effect of cardiac drugs on the prevention of OP or its progression delay.https://ter-arkhiv.ru/0040-3660/article/view/31540microcirculationsympathetic activityendothelial dysfunctionbone mineral densitynebivololosteoporosis |
| spellingShingle | I L Fedorchenko D V Nebieridze A S Safarian I A Skripnikova K E Sobchenko Cardiovascular diseases and osteoporosis: What is common? Терапевтический архив microcirculation sympathetic activity endothelial dysfunction bone mineral density nebivolol osteoporosis |
| title | Cardiovascular diseases and osteoporosis: What is common? |
| title_full | Cardiovascular diseases and osteoporosis: What is common? |
| title_fullStr | Cardiovascular diseases and osteoporosis: What is common? |
| title_full_unstemmed | Cardiovascular diseases and osteoporosis: What is common? |
| title_short | Cardiovascular diseases and osteoporosis: What is common? |
| title_sort | cardiovascular diseases and osteoporosis what is common |
| topic | microcirculation sympathetic activity endothelial dysfunction bone mineral density nebivolol osteoporosis |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31540 |
| work_keys_str_mv | AT ilfedorchenko cardiovasculardiseasesandosteoporosiswhatiscommon AT dvnebieridze cardiovasculardiseasesandosteoporosiswhatiscommon AT assafarian cardiovasculardiseasesandosteoporosiswhatiscommon AT iaskripnikova cardiovasculardiseasesandosteoporosiswhatiscommon AT kesobchenko cardiovasculardiseasesandosteoporosiswhatiscommon |