Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study
Abstract Background Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial st...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-05-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1374-2 |
| _version_ | 1818980944389865472 |
|---|---|
| author | Jia-Sian Hou Yu-Li Lin Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Yi-Maun Subeq Bang-Gee Hsu |
| author_facet | Jia-Sian Hou Yu-Li Lin Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Yi-Maun Subeq Bang-Gee Hsu |
| author_sort | Jia-Sian Hou |
| collection | DOAJ |
| description | Abstract Background Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels in hemodialysis (HD) patients. Methods Blood samples were collected from 120 HD patients, and the carotid–femoral pulse wave velocity (cfPWV) value was measured using a validated tonometry system. The cfPWV value of > 10 m/s was used to define the high artery stiffness group. Serum OPG levels were analyzed categorically into tertiles. Results Of the 120 HD patients, 53 (44.2%) were defined as the high arterial stiffness group, who had higher values of systolic blood pressure (p = 0.038), serum calcium (p = 0.007), and OPG (p < 0.001) levels and a higher prevalence of diabetes mellitus (DM, p = 0.001). Increasing tertiles of serum OPG levels were significantly associated with greater height (p = 0.011), male gender (p = 0.008), higher cfPWV values (p = 0.020), and lower intact parathyroid hormone (iPTH, p = 0.049) levels. Multivariable linear regression analysis showed that cfPWV value was independently associated with DM (β = 1.83, p = 0.008) and increasing tertiles of serum OPG levels (β = 0.89 and 1.63 for tertile 2 and tertile 3, respectively, p for trend = 0.035) in HD patients. Multivariable logistic regression analysis revealed that, in addition to age, DM, low iPTH levels, and high serum calcium levels, increasing tertiles of serum OPG levels (OR = 5.34 for tertile 2; OR = 7.06 for tertile 3; p for trend = 0.002) were an independent predictor of high arterial stiffness in HD patients. Serum calcium levels positively correlated with cfPWV value only in the highest OPG tertile group (r = 0.408, p = 0.009). Conclusion A positive association was detected between serum OPG levels and central arterial stiffness in HD patients, and patients with high serum OPG levels may have greater influence of calcium load on central arterial stiffening. |
| first_indexed | 2024-12-20T17:23:28Z |
| format | Article |
| id | doaj.art-97dd0f8abd2340678c92b6c07f594d68 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-20T17:23:28Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-97dd0f8abd2340678c92b6c07f594d682022-12-21T19:31:42ZengBMCBMC Nephrology1471-23692019-05-012011810.1186/s12882-019-1374-2Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional studyJia-Sian Hou0Yu-Li Lin1Chih-Hsien Wang2Yu-Hsien Lai3Chiu-Huang Kuo4Yi-Maun Subeq5Bang-Gee Hsu6Division of Nephrology, Buddhist Tzu Chi General HospitalDivision of Nephrology, Buddhist Tzu Chi General HospitalDivision of Nephrology, Buddhist Tzu Chi General HospitalDivision of Nephrology, Buddhist Tzu Chi General HospitalDivision of Nephrology, Buddhist Tzu Chi General HospitalDepartment of Nursing, National Taichung University of Science and TechnologyDivision of Nephrology, Buddhist Tzu Chi General HospitalAbstract Background Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels in hemodialysis (HD) patients. Methods Blood samples were collected from 120 HD patients, and the carotid–femoral pulse wave velocity (cfPWV) value was measured using a validated tonometry system. The cfPWV value of > 10 m/s was used to define the high artery stiffness group. Serum OPG levels were analyzed categorically into tertiles. Results Of the 120 HD patients, 53 (44.2%) were defined as the high arterial stiffness group, who had higher values of systolic blood pressure (p = 0.038), serum calcium (p = 0.007), and OPG (p < 0.001) levels and a higher prevalence of diabetes mellitus (DM, p = 0.001). Increasing tertiles of serum OPG levels were significantly associated with greater height (p = 0.011), male gender (p = 0.008), higher cfPWV values (p = 0.020), and lower intact parathyroid hormone (iPTH, p = 0.049) levels. Multivariable linear regression analysis showed that cfPWV value was independently associated with DM (β = 1.83, p = 0.008) and increasing tertiles of serum OPG levels (β = 0.89 and 1.63 for tertile 2 and tertile 3, respectively, p for trend = 0.035) in HD patients. Multivariable logistic regression analysis revealed that, in addition to age, DM, low iPTH levels, and high serum calcium levels, increasing tertiles of serum OPG levels (OR = 5.34 for tertile 2; OR = 7.06 for tertile 3; p for trend = 0.002) were an independent predictor of high arterial stiffness in HD patients. Serum calcium levels positively correlated with cfPWV value only in the highest OPG tertile group (r = 0.408, p = 0.009). Conclusion A positive association was detected between serum OPG levels and central arterial stiffness in HD patients, and patients with high serum OPG levels may have greater influence of calcium load on central arterial stiffening.http://link.springer.com/article/10.1186/s12882-019-1374-2OsteoprotegerinArterial stiffnessCarotid-femoral pulse wave velocityHemodialysis |
| spellingShingle | Jia-Sian Hou Yu-Li Lin Chih-Hsien Wang Yu-Hsien Lai Chiu-Huang Kuo Yi-Maun Subeq Bang-Gee Hsu Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study BMC Nephrology Osteoprotegerin Arterial stiffness Carotid-femoral pulse wave velocity Hemodialysis |
| title | Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study |
| title_full | Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study |
| title_fullStr | Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study |
| title_full_unstemmed | Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study |
| title_short | Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid–femoral pulse wave velocity in hemodialysis patients: a cross sectional study |
| title_sort | serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid femoral pulse wave velocity in hemodialysis patients a cross sectional study |
| topic | Osteoprotegerin Arterial stiffness Carotid-femoral pulse wave velocity Hemodialysis |
| url | http://link.springer.com/article/10.1186/s12882-019-1374-2 |
| work_keys_str_mv | AT jiasianhou serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT yulilin serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT chihhsienwang serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT yuhsienlai serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT chiuhuangkuo serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT yimaunsubeq serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy AT banggeehsu serumosteoprotegerinisanindependentmarkerofcentralarterialstiffnessasassessedusingcarotidfemoralpulsewavevelocityinhemodialysispatientsacrosssectionalstudy |