Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report
We present a case of transient form of type 1 pseudohypoaldosteronism (S-PHA) in a 1.5-month-old male infant who presented with lethargy, failure to thrive, severe hyponatremia (Na=118 mmol/L), hypochloremia (Cl=93 mmol/L) and fever due to urinary tract infection. Potassium levels were normal. Ma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2022-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/435573 |
| _version_ | 1797206458345979904 |
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| author | Matea Crnković Ćuk Ana Kovačević Orjena Žaja Marija Požgaj Šepec Goran Roić Bernardica Valent Morić Ivana Trutin |
| author_facet | Matea Crnković Ćuk Ana Kovačević Orjena Žaja Marija Požgaj Šepec Goran Roić Bernardica Valent Morić Ivana Trutin |
| author_sort | Matea Crnković Ćuk |
| collection | DOAJ |
| description | We present a case of transient form of type 1 pseudohypoaldosteronism (S-PHA)
in a 1.5-month-old male infant who presented with lethargy, failure to thrive, severe hyponatremia
(Na=118 mmol/L), hypochloremia (Cl=93 mmol/L) and fever due to urinary tract infection. Potassium
levels were normal. Markedly elevated serum aldosterone level and elevated serum renin confirmed
the diagnosis of pseudohypoaldosteronism. Renal ultrasound showed grade III hydronephrosis
on the left kidney while contrast-enhanced voiding urosonography excluded the existence of vesicoureteral
reflux, which raised suspicion of obstructive uropathy at the level of vesicoureteral junction.
Serum sodium normalized after several days of intravenous fluids and antibiotic therapy, after which
oral supplementation of sodium was introduced. The levels of 17-hydroxyprogesterone, adrenocorticotropic
hormone, cortisol and thyroid-stimulating hormone were normal. Functional magnetic resonance
urography conducted at the age of 3 months confirmed the diagnosis of primary congenital
obstructive megaureter and the infant was referred to a pediatric surgeon. Although a rare occurrence,
S-PHA can be a potentially life-threatening condition in infants if not recognized and treated appropriately.
Therefore, serum concentrations of electrolytes should be obtained in every child diagnosed
with obstructive anomaly of the urinary tract and/or acute cystopyelonephritis. On the other hand,
every child diagnosed with S-PHA should be evaluated for obstructive anomaly of the urinary tract. |
| first_indexed | 2024-04-24T09:07:20Z |
| format | Article |
| id | doaj.art-97dd2556a9794008b6ba05412b85e9b0 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:07:20Z |
| publishDate | 2022-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-97dd2556a9794008b6ba05412b85e9b02024-04-15T18:31:21ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512022-01-0161.471772110.20471/acc.2022.61.04.20Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case ReportMatea Crnković Ćuk0Ana Kovačević1Orjena Žaja2Marija Požgaj Šepec3Goran Roić4Bernardica Valent Morić5Ivana Trutin6Department of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Radiology, Zagreb Children’s Hospital, Zagreb, CroatiaDepartment of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaDepartment of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, CroatiaWe present a case of transient form of type 1 pseudohypoaldosteronism (S-PHA) in a 1.5-month-old male infant who presented with lethargy, failure to thrive, severe hyponatremia (Na=118 mmol/L), hypochloremia (Cl=93 mmol/L) and fever due to urinary tract infection. Potassium levels were normal. Markedly elevated serum aldosterone level and elevated serum renin confirmed the diagnosis of pseudohypoaldosteronism. Renal ultrasound showed grade III hydronephrosis on the left kidney while contrast-enhanced voiding urosonography excluded the existence of vesicoureteral reflux, which raised suspicion of obstructive uropathy at the level of vesicoureteral junction. Serum sodium normalized after several days of intravenous fluids and antibiotic therapy, after which oral supplementation of sodium was introduced. The levels of 17-hydroxyprogesterone, adrenocorticotropic hormone, cortisol and thyroid-stimulating hormone were normal. Functional magnetic resonance urography conducted at the age of 3 months confirmed the diagnosis of primary congenital obstructive megaureter and the infant was referred to a pediatric surgeon. Although a rare occurrence, S-PHA can be a potentially life-threatening condition in infants if not recognized and treated appropriately. Therefore, serum concentrations of electrolytes should be obtained in every child diagnosed with obstructive anomaly of the urinary tract and/or acute cystopyelonephritis. On the other hand, every child diagnosed with S-PHA should be evaluated for obstructive anomaly of the urinary tract.https://hrcak.srce.hr/file/435573PseudohypoaldosteronismUnilateral hydronephrosisObstructive megaureter |
| spellingShingle | Matea Crnković Ćuk Ana Kovačević Orjena Žaja Marija Požgaj Šepec Goran Roić Bernardica Valent Morić Ivana Trutin Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report Acta Clinica Croatica Pseudohypoaldosteronism Unilateral hydronephrosis Obstructive megaureter |
| title | Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report |
| title_full | Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report |
| title_fullStr | Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report |
| title_full_unstemmed | Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report |
| title_short | Transient Pseudohypoaldosteronism Secondary to Urinary Tract Infection in a Male Infant with Unilateral Hydronephrosis Due to Primary Obstructive Megaureter: A Case Report |
| title_sort | transient pseudohypoaldosteronism secondary to urinary tract infection in a male infant with unilateral hydronephrosis due to primary obstructive megaureter a case report |
| topic | Pseudohypoaldosteronism Unilateral hydronephrosis Obstructive megaureter |
| url | https://hrcak.srce.hr/file/435573 |
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