Selenium Compounds as Novel Potential Anticancer Agents
The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establ...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/3/1009 |
| _version_ | 1797409346580119552 |
|---|---|
| author | Dominika Radomska Robert Czarnomysy Dominik Radomski Krzysztof Bielawski |
| author_facet | Dominika Radomska Robert Czarnomysy Dominik Radomski Krzysztof Bielawski |
| author_sort | Dominika Radomska |
| collection | DOAJ |
| description | The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol. |
| first_indexed | 2024-03-09T04:13:07Z |
| format | Article |
| id | doaj.art-97de4c8fd12144bdae9d5adc3c7e1940 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:13:07Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-97de4c8fd12144bdae9d5adc3c7e19402023-12-03T13:57:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223100910.3390/ijms22031009Selenium Compounds as Novel Potential Anticancer AgentsDominika Radomska0Robert Czarnomysy1Dominik Radomski2Krzysztof Bielawski3Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, PolandThe high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol.https://www.mdpi.com/1422-0067/22/3/1009selenium compoundscanceranticancer agentsmolecular targetdrug resistancecombinatorial therapy |
| spellingShingle | Dominika Radomska Robert Czarnomysy Dominik Radomski Krzysztof Bielawski Selenium Compounds as Novel Potential Anticancer Agents International Journal of Molecular Sciences selenium compounds cancer anticancer agents molecular target drug resistance combinatorial therapy |
| title | Selenium Compounds as Novel Potential Anticancer Agents |
| title_full | Selenium Compounds as Novel Potential Anticancer Agents |
| title_fullStr | Selenium Compounds as Novel Potential Anticancer Agents |
| title_full_unstemmed | Selenium Compounds as Novel Potential Anticancer Agents |
| title_short | Selenium Compounds as Novel Potential Anticancer Agents |
| title_sort | selenium compounds as novel potential anticancer agents |
| topic | selenium compounds cancer anticancer agents molecular target drug resistance combinatorial therapy |
| url | https://www.mdpi.com/1422-0067/22/3/1009 |
| work_keys_str_mv | AT dominikaradomska seleniumcompoundsasnovelpotentialanticanceragents AT robertczarnomysy seleniumcompoundsasnovelpotentialanticanceragents AT dominikradomski seleniumcompoundsasnovelpotentialanticanceragents AT krzysztofbielawski seleniumcompoundsasnovelpotentialanticanceragents |