Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation

Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation

‘Don't eat me’ signal of CD47 is activated via its interaction with SIRPα protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an...

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Bibliographic Details
Main Authors: Zhiqiang Li, Xuemei Gu, Danni Rao, Meiling Lu, Jing Wen, Xinyan Chen, Hongbing Wang, Xianghuan Cui, Wenwen Tang, Shilin Xu, Ping Wang, Lei Yu, Xin Ge
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Translational Oncology
Subjects:
Luteolin
CD47-SIRPα
isoQC
Phagocytosis
Tumor immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001212

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