Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with potent effects on the regulation of antioxidant gene expression that modulates cell hemostasis under various conditions in tissues. However, the effects of Nrf2 on gastric cancer (GC) are not fully elucidated...
| প্রধান লেখক: | , , , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
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MDPI AG
2021-05-01
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| মালা: | Molecules |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.mdpi.com/1420-3049/26/11/3157 |
| _version_ | 1827691578376847360 |
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| author | Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Mohsen Azimi-Nezhad Fatemeh Forouzanfar Aranka Brockmueller Milad Ashrafizadeh Marjan Talebi Mehdi Shakibaei Saeed Samarghandian |
| author_facet | Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Mohsen Azimi-Nezhad Fatemeh Forouzanfar Aranka Brockmueller Milad Ashrafizadeh Marjan Talebi Mehdi Shakibaei Saeed Samarghandian |
| author_sort | Tahereh Farkhondeh |
| collection | DOAJ |
| description | Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with potent effects on the regulation of antioxidant gene expression that modulates cell hemostasis under various conditions in tissues. However, the effects of Nrf2 on gastric cancer (GC) are not fully elucidated and understood. Evidence suggests that uncontrolled Nrf2 expression and activation has been observed more frequently in malignant tumors, including GC cells, which is then associated with increased antioxidant capacity, chemoresistance, and poor clinical prognosis. Moreover, Nrf2 inhibitors and the associated modulation of tumor cell redox balance have shown that Nrf2 also has beneficial effects on the therapy of various cancers, including GC. Based on previous findings on the important role of Nrf2 in GC therapy, it is of great interest to scientists in basic and clinical tumor research that Nrf2 can be active as both an oncogene and a tumor suppressor depending on different background situations. |
| first_indexed | 2024-03-10T11:03:39Z |
| format | Article |
| id | doaj.art-97ded4df45d14d84b4f9f3dd5b3e74a7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:03:39Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-97ded4df45d14d84b4f9f3dd5b3e74a72023-11-21T21:18:37ZengMDPI AGMolecules1420-30492021-05-012611315710.3390/molecules26113157Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic StrategiesTahereh Farkhondeh0Ali Mohammad Pourbagher-Shahri1Mohsen Azimi-Nezhad2Fatemeh Forouzanfar3Aranka Brockmueller4Milad Ashrafizadeh5Marjan Talebi6Mehdi Shakibaei7Saeed Samarghandian8Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand 9717853577, IranFaculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, IranNoncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur 9318614139, IranMedical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, GermanyFaculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, Istanbul 34956, TurkeyDepartment of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, IranMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, GermanyNoncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur 9318614139, IranNuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with potent effects on the regulation of antioxidant gene expression that modulates cell hemostasis under various conditions in tissues. However, the effects of Nrf2 on gastric cancer (GC) are not fully elucidated and understood. Evidence suggests that uncontrolled Nrf2 expression and activation has been observed more frequently in malignant tumors, including GC cells, which is then associated with increased antioxidant capacity, chemoresistance, and poor clinical prognosis. Moreover, Nrf2 inhibitors and the associated modulation of tumor cell redox balance have shown that Nrf2 also has beneficial effects on the therapy of various cancers, including GC. Based on previous findings on the important role of Nrf2 in GC therapy, it is of great interest to scientists in basic and clinical tumor research that Nrf2 can be active as both an oncogene and a tumor suppressor depending on different background situations.https://www.mdpi.com/1420-3049/26/11/3157gastric cancerNrf2 pathwayNrf2 inhibitorantioxidants |
| spellingShingle | Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Mohsen Azimi-Nezhad Fatemeh Forouzanfar Aranka Brockmueller Milad Ashrafizadeh Marjan Talebi Mehdi Shakibaei Saeed Samarghandian Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies Molecules gastric cancer Nrf2 pathway Nrf2 inhibitor antioxidants |
| title | Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies |
| title_full | Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies |
| title_fullStr | Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies |
| title_full_unstemmed | Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies |
| title_short | Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies |
| title_sort | roles of nrf2 in gastric cancer targeting for therapeutic strategies |
| topic | gastric cancer Nrf2 pathway Nrf2 inhibitor antioxidants |
| url | https://www.mdpi.com/1420-3049/26/11/3157 |
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