Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells

Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells

Abstract Background Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); however, the molecular determinants that govern the functional role of EndoM...

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Bibliographic Details
Main Authors: Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan, Wei Wang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer-associated fibroblast
Endothelial-mesenchymal transition
Cervical squamous cell carcinoma
Lymphatic metastasis
PAI-1
Online Access:https://doi.org/10.1186/s13046-023-02714-0

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