Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study
Introduction The aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients. Methods A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-12-01
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| Series: | Pneumon |
| Subjects: | |
| Online Access: | http://www.pneumon.org/Long-term-efficacy-of-different-doses-of-steroid-nin-hospitalized-COVID-19-patients,174604,0,2.html |
| Summary: | Introduction
The aim of our study was to investigate the long-term
effects of different doses of steroid therapy given in the acute period in
hospitalized coronavirus disease 2019 (COVID-19) patients.
Methods
A total of 78 patients who were followed up in the hospital due
to COVID-19 pneumonia and were discharged from the hospital more than
3 months ago, were included in our study. The patients were divided into 3
groups according to the steroid doses they received.
Results
The value of peak expiratory flow (PEF) was significantly lower in
pulse-dose steroid group compared to high-dose steroid group (p=0.040).
There was a significant difference in the values of carbon monoxide diffusion
capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among
all groups (p=0.027, p=0.048). The values of DLCO and DLCO/VA were
significantly lower in the pulse-dose steroid group compared to the high-dose
steroid group (p=0.022, p=0.049). The computed tomography (CT) score was
significantly higher in the pulse-dose steroid group compared to both the nonsteroid
group and high-dose steroid group (p=0.027, p=0.043).
Conclusions
Pulse-dose steroid therapy given in the acute period of
COVID-19 pneumonia may negatively affect pulmonary function and recovery
in the long-term. In addition, high-dose steroids were found to have a positive
effect on pulmonary function compared to pulse-steroid therapy and nonsteroid
therapy. |
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| ISSN: | 1105-848X 1791-4914 |