Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells
Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-09-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558607800340 |
| _version_ | 1828294976792952832 |
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| author | Jane Barraclough Cassandra Hodgkinson Alison Hogg Caroline Dive Arkadiusz Welman |
| author_facet | Jane Barraclough Cassandra Hodgkinson Alison Hogg Caroline Dive Arkadiusz Welman |
| author_sort | Jane Barraclough |
| collection | DOAJ |
| description | Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, c-YesΔr6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in cYes levels/activity may promote cancer spread and metastasis rather than tumor growth. |
| first_indexed | 2024-04-13T11:47:16Z |
| format | Article |
| id | doaj.art-97e62d1d61d34a5e86f7347da5a3bfd6 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-04-13T11:47:16Z |
| publishDate | 2007-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-97e62d1d61d34a5e86f7347da5a3bfd62022-12-22T02:48:09ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022007-09-019974575410.1593/neo.07442Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma CellsJane BarracloughCassandra HodgkinsonAlison HoggCaroline DiveArkadiusz WelmanIncreases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, c-YesΔr6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in cYes levels/activity may promote cancer spread and metastasis rather than tumor growth.http://www.sciencedirect.com/science/article/pii/S1476558607800340c-Yesc-Srccolon cancerproliferationmotility |
| spellingShingle | Jane Barraclough Cassandra Hodgkinson Alison Hogg Caroline Dive Arkadiusz Welman Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells Neoplasia: An International Journal for Oncology Research c-Yes c-Src colon cancer proliferation motility |
| title | Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells |
| title_full | Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells |
| title_fullStr | Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells |
| title_full_unstemmed | Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells |
| title_short | Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells |
| title_sort | increases in c yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells |
| topic | c-Yes c-Src colon cancer proliferation motility |
| url | http://www.sciencedirect.com/science/article/pii/S1476558607800340 |
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