The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in <i>App<sup>NL-G-F</sup></i> Knock-In Mice

The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in <i>App<sup>NL-G-F</sup></i> Knock-In Mice

Background: The endocannabinoid system (ECS) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. ECS is affected in neurodegenerative disorders, such as Alzheimer’s disease (AD). Here we have evaluated the non-psychotropic endocannab...

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Bibliographic Details
Main Authors: Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambaro
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biology
Subjects:
endocannabinoid system
cannabinoid receptors
CB2
GPR55
neuroinflammation
APP knock-in mice
Online Access:https://www.mdpi.com/2079-7737/12/6/805

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