Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac arrhythmia, suggesting new therapeutic targets fo...
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Bibliographic Details
Main Authors: |
Kasper Thorsen,
Vibeke S. Dam,
Kasper Kjaer-Sorensen,
Lisbeth N. Pedersen,
V. Arvydas Skeberdis,
Jonas Jurevičius,
Rimantas Treinys,
Ida M. B. S. Petersen,
Morten S. Nielsen,
Claus Oxvig,
J. Preben Morth,
Vladimir V. Matchkov,
Christian Aalkjær,
Henning Bundgaard,
Henrik K. Jensen |
Format: | Article
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Language: | English |
Published: |
Nature Portfolio
2017-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-017-01630-0
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