Interactions of the Lysosomotropic Detergent O-Methyl-Serine Dodecylamide Hydrochloride (MSDH) with Lipid Bilayer Membranes—Implications for Cell Toxicity

Interactions of the Lysosomotropic Detergent O-Methyl-Serine Dodecylamide Hydrochloride (MSDH) with Lipid Bilayer Membranes—Implications for Cell Toxicity

O-methyl-serine dodecylamine hydrochloride (MSDH) is a detergent that accumulates selectively in lysosomes, a so-called lysosomotropic detergent, with unexpected chemical properties. At physiological pH, it spontaneously forms vesicles, which disassemble into small aggregates (probably micelles) bel...

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Bibliographic Details
Main Authors: Ana-Maria Villamil Giraldo, Ida Eriksson, Stefan Wennmalm, Timmy Fyrner, Thomas Ederth, Karin Öllinger
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
MSDH
lysosome
lysosomotropic detergent
lysosomal membrane permeabilization
liposome
Online Access:https://www.mdpi.com/1422-0067/21/9/3136

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