PEGylated Recombinant Human Growth Hormone Jintrolong® Exhibits Good Long-Term Safety in Cynomolgus Monkeys and Human Pediatric Growth Hormone Deficiency Patients

PEGylated Recombinant Human Growth Hormone Jintrolong® Exhibits Good Long-Term Safety in Cynomolgus Monkeys and Human Pediatric Growth Hormone Deficiency Patients

Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered safe, concerns persist about the potential for adve...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Wei Wu, Juan Zhou, Chuandong Wu, Qian Zhou, Xiaoyu Li, Yanlin Zhang, Conglin Zuo, Jun Yin, Ling Hou, Shuyang Wang, Hongyang Gao, Tianhong Luo, Lei Jin, Enhong Zhong, Yingwu Wang, Xiaoping Luo
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2022-07-01
Schriftenreihe:Frontiers in Endocrinology
Schlagworte:
PEG-rhGH
GHD
choroid plexus (CP)
vacuolation
MRI
TEM
Online Zugang:https://www.frontiersin.org/articles/10.3389/fendo.2022.821588/full

Online

https://www.frontiersin.org/articles/10.3389/fendo.2022.821588/full

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