| Summary: | The resistance of bacteria to the bacteriostatic and bactericidal properties of antibiotics is a major healthcare challenge that restricts the use of different types of available antibiotics. A potential alternative is to resensitize multidrug-resistant bacteria using resistance-modifying chemicals, therapies, or compounds, which act collaboratively with existing antibiotics against infections. Thus, we deliberate over the scope of various compounds, such as 2AI compounds, certain plant extracts, and other chemicals to understand their role in inducing sensitivity. One of the major components, H2S, is known to be cytotoxic and has shown various effects on bacteria. Endogenous H2S provides resistance to various bacterial species. Incidentally, an ongoing research is investigating how exogenous H2S can induce sensitivity in bacteria. Therefore, in the future, alternatives or advancements in existing antibiotics and therapies will be needed to fight bacterial diseases.
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