Compounds and Methods to Resensitize Antibiotic-resistant Bacteria
The resistance of bacteria to the bacteriostatic and bactericidal properties of antibiotics is a major healthcare challenge that restricts the use of different types of available antibiotics. A potential alternative is to resensitize multidrug-resistant bacteria using resistance-modifying chemicals,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Turkish |
| Published: |
Galenos Yayinevi
2021-12-01
|
| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | http://mjima.org/abstract.php?id=270 |
| _version_ | 1797913008653991936 |
|---|---|
| author | Priya SWAMINATHAN Suravi SEN Mandira M.A Abhirami A. PRASAD |
| author_facet | Priya SWAMINATHAN Suravi SEN Mandira M.A Abhirami A. PRASAD |
| author_sort | Priya SWAMINATHAN |
| collection | DOAJ |
| description | The resistance of bacteria to the bacteriostatic and bactericidal properties of antibiotics is a major healthcare challenge that restricts the use of different types of available antibiotics. A potential alternative is to resensitize multidrug-resistant bacteria using resistance-modifying chemicals, therapies, or compounds, which act collaboratively with existing antibiotics against infections. Thus, we deliberate over the scope of various compounds, such as 2AI compounds, certain plant extracts, and other chemicals to understand their role in inducing sensitivity. One of the major components, H2S, is known to be cytotoxic and has shown various effects on bacteria. Endogenous H2S provides resistance to various bacterial species. Incidentally, an ongoing research is investigating how exogenous H2S can induce sensitivity in bacteria. Therefore, in the future, alternatives or advancements in existing antibiotics and therapies will be needed to fight bacterial diseases. |
| first_indexed | 2024-04-10T12:06:08Z |
| format | Article |
| id | doaj.art-97e91207e2044616a485dff4ccba4875 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T12:06:08Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-97e91207e2044616a485dff4ccba48752023-02-15T16:16:18ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2021-12-0110110.4274/mjima.galenos.2021.2021.46Compounds and Methods to Resensitize Antibiotic-resistant BacteriaPriya SWAMINATHAN0https://orcid.org/0000-0003-1968-7183Suravi SEN1https://orcid.org/0000-0002-0202-0887Mandira M.A2https://orcid.org/0000-0001-5642-197XAbhirami A. PRASAD3https://orcid.org/0000-0002-8052-2268SRM Institute of Science and Technology, Department of Biotechnology, Tamil Nadu, IndiaSRM Institute of Science and Technology, Department of Biotechnology, Tamil Nadu, IndiaSRM Institute of Science and Technology, Department of Biotechnology, Tamil Nadu, IndiaSRM Institute of Science and Technology, Department of Biotechnology, Tamil Nadu, IndiaThe resistance of bacteria to the bacteriostatic and bactericidal properties of antibiotics is a major healthcare challenge that restricts the use of different types of available antibiotics. A potential alternative is to resensitize multidrug-resistant bacteria using resistance-modifying chemicals, therapies, or compounds, which act collaboratively with existing antibiotics against infections. Thus, we deliberate over the scope of various compounds, such as 2AI compounds, certain plant extracts, and other chemicals to understand their role in inducing sensitivity. One of the major components, H2S, is known to be cytotoxic and has shown various effects on bacteria. Endogenous H2S provides resistance to various bacterial species. Incidentally, an ongoing research is investigating how exogenous H2S can induce sensitivity in bacteria. Therefore, in the future, alternatives or advancements in existing antibiotics and therapies will be needed to fight bacterial diseases.http://mjima.org/abstract.php?id=270antibiotic resistanceantibioticsbacterial sensitivitycombined therapy |
| spellingShingle | Priya SWAMINATHAN Suravi SEN Mandira M.A Abhirami A. PRASAD Compounds and Methods to Resensitize Antibiotic-resistant Bacteria Mediterranean Journal of Infection, Microbes and Antimicrobials antibiotic resistance antibiotics bacterial sensitivity combined therapy |
| title | Compounds and Methods to Resensitize Antibiotic-resistant Bacteria |
| title_full | Compounds and Methods to Resensitize Antibiotic-resistant Bacteria |
| title_fullStr | Compounds and Methods to Resensitize Antibiotic-resistant Bacteria |
| title_full_unstemmed | Compounds and Methods to Resensitize Antibiotic-resistant Bacteria |
| title_short | Compounds and Methods to Resensitize Antibiotic-resistant Bacteria |
| title_sort | compounds and methods to resensitize antibiotic resistant bacteria |
| topic | antibiotic resistance antibiotics bacterial sensitivity combined therapy |
| url | http://mjima.org/abstract.php?id=270 |
| work_keys_str_mv | AT priyaswaminathan compoundsandmethodstoresensitizeantibioticresistantbacteria AT suravisen compoundsandmethodstoresensitizeantibioticresistantbacteria AT mandirama compoundsandmethodstoresensitizeantibioticresistantbacteria AT abhiramiaprasad compoundsandmethodstoresensitizeantibioticresistantbacteria |